CCL8_CANLF
ID CCL8_CANLF Reviewed; 99 AA.
AC Q68AY9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=C-C motif chemokine 8;
DE AltName: Full=Monocyte chemoattractant protein 2;
DE AltName: Full=Monocyte chemotactic protein 2;
DE Short=MCP-2;
DE AltName: Full=Small-inducible cytokine A8;
DE Flags: Precursor;
GN Name=CCL8; Synonyms=MCP2;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K.,
RA Tsujimoto H., Iwabuchi S.;
RT "Expression analysis of chemokine gene in canine atopic dermatitis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Peters I.R., Peeters D., Clercx C., Day M.J.;
RT "Identification of coding sequences for canine monocyte chemotactic
RT protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine
RT receptor 3 (CCR3).";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemotactic factor that attracts monocytes. This protein can
CC bind heparin (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer or homodimer; in equilibrium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000305}.
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DR EMBL; AB163436; BAD37149.1; -; mRNA.
DR EMBL; AY675234; AAU14059.1; -; mRNA.
DR RefSeq; NP_001005255.1; NM_001005255.1.
DR AlphaFoldDB; Q68AY9; -.
DR SMR; Q68AY9; -.
DR STRING; 9612.ENSCAFP00000027105; -.
DR PaxDb; Q68AY9; -.
DR PRIDE; Q68AY9; -.
DR Ensembl; ENSCAFT00030031804; ENSCAFP00030027731; ENSCAFG00030017255.
DR Ensembl; ENSCAFT00040021001; ENSCAFP00040018234; ENSCAFG00040011377.
DR Ensembl; ENSCAFT00845020092; ENSCAFP00845015744; ENSCAFG00845011338.
DR GeneID; 448792; -.
DR KEGG; cfa:448792; -.
DR CTD; 6355; -.
DR VEuPathDB; HostDB:ENSCAFG00845011338; -.
DR eggNOG; ENOG502S8M4; Eukaryota.
DR GeneTree; ENSGT01050000244851; -.
DR HOGENOM; CLU_141716_1_0_1; -.
DR InParanoid; Q68AY9; -.
DR OMA; SIPVTCC; -.
DR OrthoDB; 1575018at2759; -.
DR TreeFam; TF334888; -.
DR Proteomes; UP000002254; Chromosome 9.
DR Bgee; ENSCAFG00000023928; Expressed in cardiac muscle of left ventricle and 34 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl.
DR GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Heparin-binding;
KW Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250|UniProtKB:P80075"
FT CHAIN 24..99
FT /note="C-C motif chemokine 8"
FT /id="PRO_0000005187"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P80075"
FT DISULFID 34..59
FT /evidence="ECO:0000250"
FT DISULFID 35..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 99 AA; 11263 MW; FD56D8405DC010E8 CRC64;
MKFSTALLCL LLTAASFSTF VLAQPDSVSI PITCCFSMVK RKIPMQKLES YMRITNSQCP
QEAVIFKTKA SREICADPKQ KWVQDYMNHL DQKSQAQKP
