ID   CCL8_PIG                Reviewed;          99 AA.
AC   P49873;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=C-C motif chemokine 8;
DE   AltName: Full=Monocyte chemoattractant protein 2;
DE   AltName: Full=Monocyte chemotactic protein 2;
DE            Short=MCP-2;
DE   AltName: Full=Small-inducible cytokine A8;
DE   Flags: Precursor;
GN   Name=CCL8; Synonyms=MCP2, SCYA8;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7999015; DOI=10.1006/bbrc.1994.2642;
RA   Hosang K.K., Knoke I.I., Klaudiny J.J., Wempe F.F., Wuttke W.W.,
RA   Scheit K.K.;
RT   "Porcine luteal cells express monocyte chemoattractant protein-2 (MCP-2):
RT   analysis by cDNA cloning and northern analysis.";
RL   Biochem. Biophys. Res. Commun. 205:148-153(1994).
CC   -!- FUNCTION: Chemotactic factor that attracts monocytes. This protein can
CC       bind heparin.
CC   -!- SUBUNIT: Monomer or homodimer; in equilibrium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; Z48480; CAA88371.1; -; mRNA.
DR   PIR; JC2417; JC2417.
DR   AlphaFoldDB; P49873; -.
DR   SMR; P49873; -.
DR   STRING; 9823.ENSSSCP00000018777; -.
DR   PaxDb; P49873; -.
DR   PRIDE; P49873; -.
DR   Ensembl; ENSSSCT00035084710; ENSSSCP00035035237; ENSSSCG00035063005.
DR   Ensembl; ENSSSCT00065092718; ENSSSCP00065040569; ENSSSCG00065067533.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   InParanoid; P49873; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Heparin-binding;
KW   Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250|UniProtKB:P80075"
FT   CHAIN           24..99
FT                   /note="C-C motif chemokine 8"
FT                   /id="PRO_0000005191"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P80075"
FT   DISULFID        34..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..75
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  10903 MW;  D3DAA0F7A964CDB1 CRC64;
     MQVSAALLCL LLTTAAFSTQ VLAQPDSVSI PITCCFGLVN GKIPFKKLES YTRITNSQCP
     QEAVIFKTKA DKEVCADPQQ KWVQNSMKLL DQKSQTPKP