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CCL9_HUMLU
ID   CCL9_HUMLU              Reviewed;         525 AA.
AC   M4IQQ7;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Probable CoA ligase CCL9 {ECO:0000305|PubMed:23300257};
DE            Short=HlCCL9 {ECO:0000303|PubMed:23300257};
DE            EC=6.2.1.- {ECO:0000305|PubMed:23300257};
GN   Name=CCL9 {ECO:0000303|PubMed:23300257};
OS   Humulus lupulus (European hop).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Humulus.
OX   NCBI_TaxID=3486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Nugget;
RX   PubMed=23300257; DOI=10.1093/mp/sst004;
RA   Xu H., Zhang F., Liu B., Huhman D.V., Sumner L.W., Dixon R.A., Wang G.;
RT   "Characterization of the formation of branched short-chain fatty acid:CoAs
RT   for bitter acid biosynthesis in hop glandular trichomes.";
RL   Mol. Plant 6:1301-1317(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:M4IRL4}.
CC   -!- DOMAIN: Both substrate-binding domains (SBD1 and SBD2) are involved in
CC       the substrate recognition, and are sufficient to confer the substrate
CC       specificity. {ECO:0000250|UniProtKB:Q42524}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; JQ740211; AGA17926.1; -; mRNA.
DR   AlphaFoldDB; M4IQQ7; -.
DR   SMR; M4IQQ7; -.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016405; F:CoA-ligase activity; ISS:UniProtKB.
DR   CDD; cd05926; FACL_fum10p_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR045310; Pcs60-like.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Ligase; Nucleotide-binding.
FT   CHAIN           1..525
FT                   /note="Probable CoA ligase CCL9"
FT                   /id="PRO_0000452954"
FT   REGION          242..311
FT                   /note="SBD1"
FT                   /evidence="ECO:0000250|UniProtKB:Q42524"
FT   REGION          312..375
FT                   /note="SBD2"
FT                   /evidence="ECO:0000250|UniProtKB:Q42524"
FT   BINDING         171..179
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q81G39"
FT   BINDING         311..316
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q81G39"
FT   BINDING         395
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q81G39"
FT   BINDING         407..410
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q81G39"
FT   BINDING         501
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q81G39"
SQ   SEQUENCE   525 AA;  56105 MW;  E7BD3190A687F1FA CRC64;
     MANNITLTGL LKKAAAEFSD RRAILVSGEF HLTHARLQEI VDHAASLLLA SGVGHGDVVA
     LTFPNTIEYI VMFLAVIRCR AVAAPLNSAY TAEEFEFYLS DSESKLLITP PKGIEAARAA
     ASKLNITHVT ATLPGGDGLI ALSPSPNNES SLDAVAELTN DPSDVSLFLH TSGTTSRPKG
     VPLTQLNLAS SVQNIKSVYK LSESDSTVVV LPLFHVHGMI AGLLSSLIAG SAVTLPAAGR
     FSASTFWSDM IACNATWYTA VPTIHQIILD RHLNKPEPTY PKLRFIRSCS ASLAPTIMGR
     LEESFGAPVL EAYAMTEAAH LMASNPLPED GGHKPGSVGK PVGQEMAILD LNGSAQLPGF
     SGEVCIRGPN VTKGYKNNPE ANKAAFQFGW FHTGDVGYFD EDGYLHLVGR IKELINRGGE
     KISPIEVDAV LLSHPDLAQA VAFGVPDDKY GEEINCAVIP REGSEVDEDG VLRFCKKNLA
     AFKVPKKVFI TDSLPKTATG KIQRRIVAEH FLAQISTAKV PKFGA
 
 
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