ID   CCM1_ASHGO              Reviewed;         855 AA.
AC   Q752U3;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; OrderedLocusNames=AFR480C; ORFNames=AGOS_AFR480C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53851.1; -; Genomic_DNA.
DR   RefSeq; NP_986027.1; NM_212163.1.
DR   AlphaFoldDB; Q752U3; -.
DR   SMR; Q752U3; -.
DR   STRING; 33169.AAS53851; -.
DR   EnsemblFungi; AAS53851; AAS53851; AGOS_AFR480C.
DR   GeneID; 4622306; -.
DR   KEGG; ago:AGOS_AFR480C; -.
DR   eggNOG; ENOG502QUX2; Eukaryota.
DR   HOGENOM; CLU_334653_0_0_1; -.
DR   InParanoid; Q752U3; -.
DR   OMA; RALYYKY; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IEA:EnsemblFungi.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:2000234; P:positive regulation of rRNA processing; IEA:EnsemblFungi.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0016072; P:rRNA metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF13041; PPR_2; 1.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   PROSITE; PS51375; PPR; 3.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..855
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402255"
FT   REPEAT          234..265
FT                   /note="PPR 1"
FT   REPEAT          317..351
FT                   /note="PPR 2"
FT   REPEAT          354..388
FT                   /note="PPR 3"
FT   REGION          29..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   855 AA;  97409 MW;  388D79E8725ADCB1 CRC64;
     MILKSELLDV HTRLGQMLPF VTKRFASVPT AMRTRRRTRR HEREPNLRKR QGGSHSNLKE
     NEDAELKFKL RQMNEFAKNL KMQMQLADSL RRKEEAARAE GIGGDVAEGA IERDSSTVAA
     ALLEGAEPAE AQPAPLNLSQ LIMSAQNAEP LLAPELAERI GDGKLVYSAL VNKRAQNWDA
     IVAALYESAE KLRGLDADIV KEKLLLRVSG LSLEGVATLD KLLTDRFGEG RDFDVDMYGV
     LFETLGEHTQ HTQQAKTVVD RMKKLLQRYD ACDDPDKKPL TQEILNCCLK VGTAAKSFDD
     MNYFLSKFVK DYRILPNKVN YDQVLTFYLK NRTLSQAWET FGAMKFMSLS HRPDVATYNL
     MLQVCDQERN YSKALDLYHE IQDLKMEPDV RTLSMLAKAM ASASTDAIVS EGKSDSLRLT
     GWKFIHEIEN NPKYATAKDD PVCAHGVLTT MMALASYDGD VGLARALFYR HAVQSYKKLM
     KNANMDAVSN PAAAARAAWT QAIDPVLFNY LLMAYSRYQP NKLPILLGYE LGAKFRRQLM
     FNVDYMGRAE SDNDMHANIP LLPVMELSST AEVLNESRAL WEFFLSKHIN GSLQPQPSAR
     VVSMLEEYRQ NHDTFEGFMK EVKSQVKRWQ WHAVNRRLMT PITIMSYLSI PLRLGSYEEF
     AFRYKQTIYT GNELEESVKN FYDPALVTVS DEATVVVDDS EVKVEKYARK IDDRILQIYS
     FAYKNRVYND VFELAMKAAT KFRDNSLATR VWKERGEFRK TEGYTSMSVK DRIAGDTSFA
     CATVKFFVAE KRFSEAMAVI MSSQKYIDWK YHMVRELHNA LVSIEDSVSI RKLLSVVNKQ
     NRLKVLNTES PSLTP