ID   CCM1_CANAW              Reviewed;         770 AA.
AC   C4YSG0;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; ORFNames=CAWG_05026;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; CM000312; EEQ46663.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YSG0; -.
DR   STRING; 5476.C4YSG0; -.
DR   EnsemblFungi; EEQ46663; EEQ46663; CAWG_05026.
DR   VEuPathDB; FungiDB:CAWG_05026; -.
DR   HOGENOM; CLU_019745_0_0_1; -.
DR   OMA; RALYYKY; -.
DR   Proteomes; UP000001429; Chromosome 6.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF01535; PPR; 2.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   PROSITE; PS51375; PPR; 6.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Repeat; Transit peptide.
FT   TRANSIT         1..90
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           91..770
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402257"
FT   REPEAT          276..310
FT                   /note="PPR 1"
FT   REPEAT          311..346
FT                   /note="PPR 2"
FT   REPEAT          349..383
FT                   /note="PPR 3"
FT   REPEAT          384..419
FT                   /note="PPR 4"
FT   REPEAT          420..454
FT                   /note="PPR 5"
FT   REPEAT          636..666
FT                   /note="PPR 6"
FT   REGION          28..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          90..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   770 AA;  88722 MW;  754D6D37E32CBE9A CRC64;
     MIRLILWNNV QSLVFKRCLF VPSNSLTNKR KRRIPPSKPR SSNRKDGDIE PYRMTDQNQT
     PNTGSIARLP AEVKKELKDL RSFTKVIAQH LKPEQENDSL TSAEKPDTSQ LPPIDIEEAT
     DDIFGEISGT KKLSANAVPP PPPPPPPGLD IPDEIKERLG LLSELLVPAK TSNNKLPEKQ
     VENNWKLLLS QLDQAGGLSG LSKRSVSKFF SKIPPKNLKN LIPMIENMYN KAEMSIPHPI
     YYMFVRSLTL GDKISDSQMQ LINKYFQEIS KQTDLKIDHY ETMILAYVKN NHMEKIDGIL
     AQMKKKNIEI SKMIYTSIVR GYIFYQKDHQ RALDTFDSMK FLSQKTQPDE KVYTDVIVSC
     VMHREIERAL DLYYELKDKG MNVNQNLLST LAKGCSRSKQ FKTQAWNFLF QVYDHGWVPN
     LQTYEHMLYI AARDGDVELT RVLFYKMLQT NSVTIRAFRY LILSYSKYVP PHKRKEKHLI
     LLNHKGQLFR QNILQDVDFS KPVHGFPFLP SSHIPDSKFV LAESSAIWAH TVMNNPSFLR
     QQTLVASYVS IALELGDFTE FKDRFDSASY LNTDGIPKVR EIEIIEPRQD EPTEKATTTE
     EQITSSEPDT NSLIRSPILN QLQQNINDNQ FKAPRDSYLY NLAIKAAGKF KDYSFAQQIL
     HERGQFRKSN SFKLLSPKQQ NQDDFQFAGY LVECWTNMNL LEDAYAVVLS SVDRFPWSWR
     ELGVLNNAAM KLGSLELAEA VRKVAQVTQV KHHGKIKRQD FKTYVMKRGY