ID   CCM1_CANTT              Reviewed;         753 AA.
AC   C5M5D9;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; ORFNames=CTRG_02117;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; GG692396; EER35255.1; -; Genomic_DNA.
DR   RefSeq; XP_002547810.1; XM_002547764.1.
DR   AlphaFoldDB; C5M5D9; -.
DR   STRING; 5482.XP_002547810.1; -.
DR   EnsemblFungi; EER35255; EER35255; CTRG_02117.
DR   GeneID; 8297214; -.
DR   KEGG; ctp:CTRG_02117; -.
DR   VEuPathDB; FungiDB:CTRG_02117; -.
DR   eggNOG; ENOG502QUX2; Eukaryota.
DR   HOGENOM; CLU_019745_0_0_1; -.
DR   OrthoDB; 531312at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR033443; PPR_long.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF17177; PPR_long; 1.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   PROSITE; PS51375; PPR; 5.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..76
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           77..753
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402260"
FT   REPEAT          262..296
FT                   /note="PPR 1"
FT   REPEAT          297..332
FT                   /note="PPR 2"
FT   REPEAT          335..369
FT                   /note="PPR 3"
FT   REPEAT          370..405
FT                   /note="PPR 4"
FT   REPEAT          406..441
FT                   /note="PPR 5"
SQ   SEQUENCE   753 AA;  86395 MW;  59AD500BD4A2185E CRC64;
     MLRHTRNKCL SIIPRRYLFV PSNSFTDSKK KNVIRAKPRV KSTPKIMEDE AHQKKPQIDK
     SLIAKAKKDL RELRSLAKDV SEYIEPKDID SLTTTKKIST ELPPIDIDEA TEDIFQEISD
     SKGKMKKHPK ALPPSLSFPE KINQRLGLVS DLLVSRESTS NLPEKTRNDK WNILLTQLNA
     AGGFKELSEV DIRSFVNKIP LRSLRNLIPF IENMYHEAGV SVHYNTYYSF IRALSLGASI
     SDTQIQVIEG YFNEIEKQTE LKMDHYETKI AVYVKNKNKK KIEEVLGVMK AKNLPLSKSI
     YKSILSSYVY YTKDHRRAIE VFDSMKFLSE STKPDAKVYA QIIISCMMND DIDKGLDLLQ
     EMRDNNVKPN QSILSALAKG CARSRQHKFQ AWNHLFQIYE YGWTPTLQTF EHMLYISAKD
     GDVELTRALF YKMLETNSVT PSAFISLMLA YANYQSPTSR TEPFLVSLTE NGRLFKQNIM
     ANVDFSKPIH GFPFLPTSRI PDGKFILAES SAIWAYTIMH NPSFVNNPHV AAPYLNIAYE
     LGEFNDFKDR LNESTYLNDE GIPKVREIEI IEPNEETESP DSELQVVEPN ENDTGLVKSP
     ILNKLSGHLK DNRHKAPRDS MIYQIALDAA GKFKKFDFAQ EIIKERGQFR KSNMFKKLSS
     KEQTKQDFQF AEKLVYCYVK MNLIEDAYSV VLSSVDRFPW GWKQLVPLNT AAINLGSSEL
     AAAVRKIAQS NQVKHHGKIK SNDYKKYVMK RGY