ID   CCM1_CLAL4              Reviewed;         750 AA.
AC   C4Y2K4;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; ORFNames=CLUG_02767;
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; CH408078; EEQ38641.1; -; Genomic_DNA.
DR   RefSeq; XP_002617323.1; XM_002617277.1.
DR   AlphaFoldDB; C4Y2K4; -.
DR   STRING; 306902.C4Y2K4; -.
DR   EnsemblFungi; EEQ38641; EEQ38641; CLUG_02767.
DR   GeneID; 8497634; -.
DR   KEGG; clu:CLUG_02767; -.
DR   VEuPathDB; FungiDB:CLUG_02767; -.
DR   HOGENOM; CLU_019745_0_0_1; -.
DR   InParanoid; C4Y2K4; -.
DR   OMA; RALYYKY; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF01535; PPR; 2.
DR   TIGRFAMs; TIGR00756; PPR; 2.
DR   PROSITE; PS51375; PPR; 4.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..750
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402261"
FT   REPEAT          263..297
FT                   /note="PPR 1"
FT   REPEAT          298..333
FT                   /note="PPR 2"
FT   REPEAT          336..370
FT                   /note="PPR 3"
FT   REPEAT          371..406
FT                   /note="PPR 4"
SQ   SEQUENCE   750 AA;  85024 MW;  C57DE9DC91438AA7 CRC64;
     MFIGKKAPAA LRKQLWPVFP TYNILGSRNI YVMSHERRKK AAKRKSDKLQ QWAEQEEMRL
     AREKNQQYAK KLKELKQLTR SVASYVRTRE ARELEAQKIQ ELSLPSELGK GSEPAGLAAP
     RSAKIAPFDA SAASLSTSAV PLPQSIQDRL GLAVKYLVSK DHQNWSIVLQ QLEAAGGFDG
     LPQKDIRKMV YAIPKDQLRH VFPQIESLLG QAGLAVSPKL LNTYIKSLML GRTLNDAQIA
     YIEGIVAKLR QEPGKEGKLG KLSRATYELL IEAYGKNTNV AKMNEVIQEM KELGLQLSPV
     VYTNVLSTCV YKTRDHQQAV KLFDSMKFLA GSMAPQTREY QDIIVSYVNN DDIEKALDLY
     QEMLDQKLDF NQNIMVALAR GCMSREQLRF KAWDFIFEIY RCGWEPTANT LEYMLYLASK
     DGDLALARAL YQQLNISNAL SPRAFSFLFL AYARSNVGKS IEEFQPFAIT VHEEGRNFRR
     NILEKVDLTP TTENPKQAVP YLPKISLSTP QEVLAESSAV MAHALMVNRE FVNVESVTTF
     LNVAARMGSL DDFIDRYEEF TFLDKTGVTE TKTVIEPEIL ESTSVLLAPK EPSPTKSPIL
     AQVTESQKSA FKMPRNTITY LIALKAAAKH KNYIFAQKVW TERGTYRKSA GFRNLPKSEK
     EKLDFSFASG MVNCLTDMKL LDDALAILVS TEYQFKWTWK ELSHLYAAAA EAGYDKVTKT
     IRGVVKRAQI NFEGKIRRKD YKKYVMERGY