ID   CCM1_KLULA              Reviewed;         853 AA.
AC   Q6CNQ2;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; OrderedLocusNames=KLLA0E10803g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99524.1; -; Genomic_DNA.
DR   RefSeq; XP_454437.1; XM_454437.1.
DR   AlphaFoldDB; Q6CNQ2; -.
DR   SMR; Q6CNQ2; -.
DR   STRING; 28985.XP_454437.1; -.
DR   EnsemblFungi; CAG99524; CAG99524; KLLA0_E10803g.
DR   GeneID; 2893680; -.
DR   KEGG; kla:KLLA0_E10803g; -.
DR   eggNOG; ENOG502QUX2; Eukaryota.
DR   HOGENOM; CLU_334653_0_0_1; -.
DR   InParanoid; Q6CNQ2; -.
DR   OMA; RALYYKY; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019843; F:rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0000963; P:mitochondrial RNA processing; IEA:EnsemblFungi.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:2000234; P:positive regulation of rRNA processing; IEA:EnsemblFungi.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0016072; P:rRNA metabolic process; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF01535; PPR; 2.
DR   PROSITE; PS51375; PPR; 2.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..853
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402263"
FT   REPEAT          310..344
FT                   /note="PPR 1"
FT   REPEAT          347..381
FT                   /note="PPR 2"
SQ   SEQUENCE   853 AA;  99225 MW;  C78128147DCA1C06 CRC64;
     MLSLGKNGKT SSTLVRNARR SVIMPASRDV RSRKRRARSV TDTKDVLDLD SIDFTNEKEV
     QFKVNQLKEF TRNLREQIKY TDELKRKHVI EEEETKSVDP EMHDFDSDAG VILSSLNDKV
     AGPGAEQNLS TLLLSDKADT SLLPERLSER IKDKDLILRC LFDKRNRDFN PIVTELYHSE
     QRLKGLGIQF IYSKILSKFD KLSFTSLSQL DEMIMESVGN DSSRLNGNLY EHLMLSFSRV
     TSPSAQGKLE VCGKLRELTE RMDATLSKKS FQPTQYMLNA CIFAASKAMS WEYMDFFLKK
     FTSTYDMQPN RKNYTTVISF YTKMEHYKKA WQLFDSLKFL SLEHKPDTKV YNLMLEVCQK
     EKNYARSLDI FQEMDDLNVT KDLKTYLNAA KSLALSSADN VTSEGKADSL RLMSWKYIHK
     IHDDPKLSKQ LTENPRNNML LLETMMVLSA YDGDVGFARA LYYKYTNALF KAHFYEFKKY
     HKDTDPVDYI RIWKKSLSAQ MFNWLMLSYS KFKKSRLPVL LGYPEGSSLR RSMIYSVDYS
     GRDSSYENSN IQLPMLPMTE LNDAELTINE SKALWRFNLE FGGNYDIREL PEGMQTVKDI
     ENIVKCAKTV NEFKLQISQR LLEWKNRYVN HKILNMKSLI TFLTIPIRLH EPNEFKLRLQ
     EFTFQAFEFN ERVEYQFKKS KTNELESPVL SKDFNTTDSN ALVDNGIIPS EFLLYLVSMK
     HKLATNCAIY EVSMKAAIAF HDYELAMTTW KNRGKFRMTD AFQKLTPGER QQSDATFAQL
     MVEYFTNEKM YQDALSIILS SLKTVNWQYS MVKSLHRALL AIEDENSAAR LLSVVNRKSK
     IVELEEEIKS LDL