CCM1_KOMPG
ID CCM1_KOMPG Reviewed; 725 AA.
AC C4R5P7;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE Flags: Precursor;
GN Name=CCM1; OrderedLocusNames=PAS_chr3_1225;
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864;
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC I introns in mitochondrial encoded transcripts. Maintains the stability
CC of the small subunit mitochondrial 15S rRNA and thus the expression of
CC the mitochondrial genome (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR EMBL; FN392321; CAY70883.1; -; Genomic_DNA.
DR RefSeq; XP_002493062.1; XM_002493017.1.
DR AlphaFoldDB; C4R5P7; -.
DR STRING; 644223.C4R5P7; -.
DR PRIDE; C4R5P7; -.
DR EnsemblFungi; CAY70883; CAY70883; PAS_chr3_1225.
DR GeneID; 8200322; -.
DR KEGG; ppa:PAS_chr3_1225; -.
DR eggNOG; ENOG502QUX2; Eukaryota.
DR HOGENOM; CLU_019745_0_0_1; -.
DR InParanoid; C4R5P7; -.
DR OMA; RALYYKY; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
PE 3: Inferred from homology;
KW Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW Transit peptide.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 29..725
FT /note="Mitochondrial group I intron splicing factor CCM1"
FT /id="PRO_0000402266"
FT REPEAT 189..223
FT /note="PPR 1"
FT REPEAT 224..259
FT /note="PPR 2"
FT REPEAT 260..290
FT /note="PPR 3"
FT REPEAT 296..330
FT /note="PPR 4"
FT REPEAT 333..363
FT /note="PPR 5"
FT REPEAT 401..435
FT /note="PPR 6"
FT REPEAT 601..635
FT /note="PPR 7"
SQ SEQUENCE 725 AA; 84412 MW; 4E7501F424D83710 CRC64;
MRLSRIGTPK VSVTRVIPVR NVVIARRKPV RASNTDAKTW LMKEEQRRIR QKEQEMKQRL
EELERFKTKV QKSYIRKEDR HLAQEIEKDL DIITDDYNLD SDVDLVFGEL MQAEEQPKSL
KSLPGASDAS DNTDKSVELF SFPSPNLTLP EKVIHHIGPL VKHISNPENI QWGRLLLDLE
KNQGFNGLSA VDVTRLIQNI PKEEKYQHMS LIHEMMFNSG ISPDRYLTDL MMTAFSERSY
YEPLVEALFQ DYDINGWAPT DYTFGALIKV YSKGKKLDKI NNLLNQMKLK YHKEPNKKIY
TMVLQTCMKI DDYKKTSEVF DAMKFNSVAT NPDTTAYGSM ILMHVLNDNV EAALDLYDNL
ETEPDETILL ALARGCSSRK VLINRGWDFI IEYYKRKFPL NEKLMTVMMY LTSRDGDLSL
TRAIYNTIHE SRFKMTESFS MNKNDGIALN VLLRGYFKYP DNHTVQSKTN DAVVALRRST
LALNHFGYHP KATPFLPVNE LEEKHILPEV QAIWSYIILH YPDIVTSELV GTYLMILATR
GSMADFNKAF EELTLKPVFE QVDNAVAVEE ESEQSSELSD LRLTPLAIRL SSNIQIKYPR
NHDIYHIALQ ACINNKDIEL GQRIWQERGR FRKTPEFSMQ PRNVKHNQDF EFARDMLKLL
VNCNELNDAC RLLLSTETQF NWEWTYVKPV YIMAEQLGDE YAKKVVRRVV RNKKSKWREE
YLQGM