ID   CCM1_LACTC              Reviewed;         871 AA.
AC   C5DHU5;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; OrderedLocusNames=KLTH0E07194g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23356.1; -; Genomic_DNA.
DR   RefSeq; XP_002553793.1; XM_002553747.1.
DR   AlphaFoldDB; C5DHU5; -.
DR   STRING; 559295.C5DHU5; -.
DR   EnsemblFungi; CAR23356; CAR23356; KLTH0E07194g.
DR   GeneID; 8291948; -.
DR   KEGG; lth:KLTH0E07194g; -.
DR   eggNOG; ENOG502QUX2; Eukaryota.
DR   HOGENOM; CLU_334653_0_0_1; -.
DR   InParanoid; C5DHU5; -.
DR   OMA; RALYYKY; -.
DR   OrthoDB; 531312at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF13041; PPR_2; 1.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   PROSITE; PS51375; PPR; 2.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..72
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           73..871
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402264"
FT   REPEAT          333..369
FT                   /note="PPR 1"
FT   REPEAT          370..404
FT                   /note="PPR 2"
FT   REGION          704..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   871 AA;  99353 MW;  16368A1B2FE934F3 CRC64;
     MLGRRLAGAK PQSGALFKRF VVIPASSKAR RRRRDVGGIR KNVSVEELEL DKALDLRDPK
     ELEFKLRQLR EFTKNLATQI RVADDLVKKE AAQKELGNKS KEEDTADAAS VILGTHNHHD
     RYQRRSLLQG EDLSSIILSV SHQVKKLLPE AILKRINDDE LVLRSLINHR NSDWNAIISK
     LDQSPEKLDG VSQRALKNYI LSKAKNLSLG SIRKADAMLL SNINHDLTKF NTSMYEFLFY
     NLSNLKPSQD PSSKYNNEVY TVMESLLDRY DEAQKVIAGK NVAIEAQEGI MPKVEMNQFI
     LNCCIKFASK LLDVSKMNRF LTKFNRDYHI LPNKENYTVI AQFYTKLGLH DKAWDIFATM
     KFLSADHKPD AKTYTCMLSL CNKEKNYAKA IDLFNEMIDL KVDPTPETLN ALVKTLATVS
     GDPVASEGKA ESLRLLAWKY LHQNEDLVNL RSGNFEDTIL AMMSLCAYDG DAGLARALYF
     KYITTRFKSN FESWRMRQGD HSSVDYKKVW ASTLNPFLFN YLMLAYANYS PGKLPLLLGF
     EQGAVTRRNL INNVDYLYKF QNDEAGPRAK LPMLPLADIS EPSQILLESR AVWQFNLEFG
     GLCDLRISPL GSSKVLKDLA ASAESIEDFS FQVLHQIALW KTQIVNHNAL NPKSIMTYLT
     IPLKLGEKKE FLLRMSEFSY EQQTFEQHIS SLYMNTKQQL LTARPGSSTH LTHSEIKKQP
     SSQTSFNEES SLAFLSSMKH KIIRNSSIYE LTMKAAIRFQ DQALATKAWE SRGSYRKTLA
     FQNLPVAERT KKDAAFASLM VDFFTQQQMY TDAMGIIMAS QRHISWRYPM VKRLHRKLVE
     LEDTRSIKIL MEIVNKRSKS DSSAEAVTSL G