ID   CCM1_PICGU              Reviewed;         644 AA.
AC   A5DA73;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Mitochondrial group I intron splicing factor CCM1;
DE   Flags: Precursor;
GN   Name=CCM1; ORFNames=PGUG_00178;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding protein involved in the specific removal of group
CC       I introns in mitochondrial encoded transcripts. Maintains the stability
CC       of the small subunit mitochondrial 15S rRNA and thus the expression of
CC       the mitochondrial genome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCM1 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36080.2; -; Genomic_DNA.
DR   RefSeq; XP_001486801.1; XM_001486751.1.
DR   AlphaFoldDB; A5DA73; -.
DR   SMR; A5DA73; -.
DR   STRING; 4929.XP_001486801.1; -.
DR   EnsemblFungi; EDK36080; EDK36080; PGUG_00178.
DR   GeneID; 5129538; -.
DR   KEGG; pgu:PGUG_00178; -.
DR   VEuPathDB; FungiDB:PGUG_00178; -.
DR   eggNOG; ENOG502QUX2; Eukaryota.
DR   HOGENOM; CLU_019745_0_0_1; -.
DR   InParanoid; A5DA73; -.
DR   OMA; RALYYKY; -.
DR   OrthoDB; 531312at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR002885; Pentatricopeptide_repeat.
DR   InterPro; IPR033443; PPR_long.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF13812; PPR_3; 1.
DR   Pfam; PF17177; PPR_long; 1.
DR   TIGRFAMs; TIGR00756; PPR; 2.
DR   PROSITE; PS51375; PPR; 3.
PE   3: Inferred from homology;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome; Repeat;
KW   Transit peptide.
FT   TRANSIT         1..38
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..644
FT                   /note="Mitochondrial group I intron splicing factor CCM1"
FT                   /id="PRO_0000402265"
FT   REPEAT          245..279
FT                   /note="PPR 1"
FT   REPEAT          280..315
FT                   /note="PPR 2"
FT   REPEAT          318..352
FT                   /note="PPR 3"
FT   REGION          78..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  73477 MW;  E63233F596D5A350 CRC64;
     MVIVASSNML RPDRIWLCGK YQTARTLYVV GNKSKRRNPS LEDWARSDSD RKMKLQQQEY
     NRKLKELKNL TANVSKMISK KSEKEVERSQ IQSTEPSPET STQLTQKNDS QRLDFLAKKS
     LFIPVVDIPA SVSDRIGLAF KYLVSKSSQN WSMVLDQLEK NGGFKDIPSK DIRKFVYQIP
     KPHIPPIISR LKKMHHDAGV PVSPKLVNVF IDSLLLSPSI PSSVMSQIES YCDSIRSTSK
     KGRLPRETYE LLIRAYGKNS NLEMVNSILT EMKQVGLQPS KNTFENILAT SVYKSKDHKQ
     AVEVFDTMKF LSDKTKPAER AYRDIIVSYV NNDDIEKALD LYNEMVENKV EVSQQIMVAL
     ARGCISRPEL KVKAWEFIFE IYNQKWEPTI QTLEYVLYLA AKDGDVALCR ALVNKLSETS
     SVTVRSFSFL LLGYSKSSLY NESPSIPPIL AHENGIRFRR NILADSSYAP SSESSLPFLP
     VLDLVTEKEI LAESSAMWAY ANTIRPDLIN IESANTYLNI GAKFGSLKEF LDRYNSATLL
     DRQGVPDTRV IEDENLAEVS VMDYTSTASV RSPLLDRNHT LKVPRDDMTY LIALKAASKA
     RNYEFSQEVW SERGLYRKSD RIRLSQEQKR TNLIFNLQSL WSQL