ID   CCMA_ECOUT              Reviewed;         207 AA.
AC   Q1R9L8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule:MF_01707};
DE            EC=7.6.2.5 {ECO:0000255|HAMAP-Rule:MF_01707};
DE   AltName: Full=Heme exporter protein A {ECO:0000255|HAMAP-Rule:MF_01707};
GN   Name=ccmA {ECO:0000255|HAMAP-Rule:MF_01707}; OrderedLocusNames=UTI89_C2479;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in the
CC       biogenesis of c-type cytochromes; once thought to export heme, this
CC       seems not to be the case, but its exact role is uncertain. Responsible
CC       for energy coupling to the transport system. {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate;
CC         Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01707};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CcmA) and
CC       two transmembrane proteins (CcmB). {ECO:0000255|HAMAP-Rule:MF_01707}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA exporter
CC       (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule:MF_01707}.
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DR   EMBL; CP000243; ABE07946.1; -; Genomic_DNA.
DR   RefSeq; WP_000525586.1; NZ_CP064825.1.
DR   AlphaFoldDB; Q1R9L8; -.
DR   SMR; Q1R9L8; -.
DR   EnsemblBacteria; ABE07946; ABE07946; UTI89_C2479.
DR   KEGG; eci:UTI89_C2479; -.
DR   HOGENOM; CLU_000604_1_2_6; -.
DR   OMA; NLAWLCA; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015439; F:ABC-type heme transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR005895; ABC_transptr_haem_export_CcmA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43499; PTHR43499; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01189; ccmA; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51243; CCMA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane;
KW   Cytochrome c-type biogenesis; Membrane; Nucleotide-binding; Translocase;
KW   Transport.
FT   CHAIN           1..207
FT                   /note="Cytochrome c biogenesis ATP-binding export protein
FT                   CcmA"
FT                   /id="PRO_0000271922"
FT   DOMAIN          4..207
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
SQ   SEQUENCE   207 AA;  22954 MW;  73225E60C6FAEC4A CRC64;
     MGMLEARELL CERDERTLFS GLSFTLNAGE WVQITGSNGA GKTTLLRLLT GLSRPDAGEV
     LWQGQPLHQV RDSYHQNLLW IGHQPGIKTR LTALENLHFY HRDGDTAQCL EALAQAGLAG
     FEDIPVNQLS AGQQRRVALA RLWLTRATLW ILDEPFTAID VNGVDRLTQR MAQHTEQGGI
     VILTTHQPLN VAESKIRRIS LTQTGAA