ID   CCMA_ROSDO              Reviewed;         206 AA.
AC   Q166I9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule:MF_01707};
DE            EC=7.6.2.5 {ECO:0000255|HAMAP-Rule:MF_01707};
DE   AltName: Full=Heme exporter protein A {ECO:0000255|HAMAP-Rule:MF_01707};
GN   Name=ccmA {ECO:0000255|HAMAP-Rule:MF_01707}; OrderedLocusNames=RD1_2547;
OS   Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp.
OS   (strain OCh 114)) (Roseobacter denitrificans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseobacter.
OX   NCBI_TaxID=375451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33942 / OCh 114;
RX   PubMed=17098896; DOI=10.1128/jb.01390-06;
RA   Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H.,
RA   Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K.,
RA   O'Huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T.,
RA   Touchman J.W.;
RT   "The complete genome sequence of Roseobacter denitrificans reveals a
RT   mixotrophic rather than photosynthetic metabolism.";
RL   J. Bacteriol. 189:683-690(2007).
CC   -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in the
CC       biogenesis of c-type cytochromes; once thought to export heme, this
CC       seems not to be the case, but its exact role is uncertain. Responsible
CC       for energy coupling to the transport system. {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate;
CC         Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01707};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CcmA) and
CC       two transmembrane proteins (CcmB). {ECO:0000255|HAMAP-Rule:MF_01707}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA exporter
CC       (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule:MF_01707}.
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DR   EMBL; CP000362; ABG32104.1; -; Genomic_DNA.
DR   RefSeq; WP_011568721.1; NZ_FOOO01000002.1.
DR   AlphaFoldDB; Q166I9; -.
DR   SMR; Q166I9; -.
DR   STRING; 375451.RD1_2547; -.
DR   EnsemblBacteria; ABG32104; ABG32104; RD1_2547.
DR   KEGG; rde:RD1_2547; -.
DR   eggNOG; COG4133; Bacteria.
DR   HOGENOM; CLU_000604_1_2_5; -.
DR   OMA; GITHLPF; -.
DR   OrthoDB; 1833499at2; -.
DR   Proteomes; UP000007029; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015439; F:ABC-type heme transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR005895; ABC_transptr_haem_export_CcmA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43499; PTHR43499; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01189; ccmA; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51243; CCMA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane;
KW   Cytochrome c-type biogenesis; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..206
FT                   /note="Cytochrome c biogenesis ATP-binding export protein
FT                   CcmA"
FT                   /id="PRO_0000271953"
FT   DOMAIN          3..206
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
FT   BINDING         35..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
SQ   SEQUENCE   206 AA;  21364 MW;  E7791F66D7C7292B CRC64;
     MTVSVDDLCV TRGGVPILSG VSFDLAEGAA LILQGPNGSG KTTLLRTLAG LQPPLAGQIS
     GTEDRIAYAA HSDGLKSMLS VAENLRFWAA VFGRSDIAPA LQAFDLHDLA DRLAGTLSAG
     QKRRLGLARL LVTGRPVWML DEPTVSLDKR AVEMFAAAVE AHLATGGSAL IATHIDLGLR
     DAQVLDVGPL RASPTALAGA SDEAFL