CCMB_ARATH
ID CCMB_ARATH Reviewed; 206 AA.
AC P93280;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Putative cytochrome c biogenesis ccmB-like mitochondrial protein;
DE AltName: Full=ABC transporter I family member 2;
DE Short=ABC transporter ABCI.2;
DE Short=AtABCI2;
GN Name=CCMB; Synonyms=ABCI2, CCB2, CCB206; OrderedLocusNames=AtMg00110;
OS Arabidopsis thaliana (Mouse-ear cress).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. C24;
RX PubMed=8988169; DOI=10.1038/ng0197-57;
RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.;
RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in
RT 366,924 nucleotides.";
RL Nat. Genet. 15:57-61(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324;
RA Giege P., Brennicke A.;
RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in
RT ORFs.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be involved in the export of heme to the mitochondrion
CC for the biogenesis of c-type cytochromes.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=6 {ECO:0000269|PubMed:10611383}, 10
CC {ECO:0000269|PubMed:10611383}, 24 {ECO:0000269|PubMed:10611383}, 27
CC {ECO:0000269|PubMed:10611383}, 43 {ECO:0000269|PubMed:10611383}, 46
CC {ECO:0000269|PubMed:10611383}, 50 {ECO:0000269|PubMed:10611383}, 52
CC {ECO:0000269|PubMed:10611383}, 54 {ECO:0000269|PubMed:10611383}, 55
CC {ECO:0000269|PubMed:10611383}, 58 {ECO:0000269|PubMed:10611383}, 60
CC {ECO:0000269|PubMed:10611383}, 61 {ECO:0000269|PubMed:10611383}, 63
CC {ECO:0000269|PubMed:10611383}, 65 {ECO:0000269|PubMed:10611383}, 96
CC {ECO:0000269|PubMed:10611383}, 102 {ECO:0000269|PubMed:10611383}, 113
CC {ECO:0000269|PubMed:10611383}, 123 {ECO:0000269|PubMed:10611383}, 127
CC {ECO:0000269|PubMed:10611383}, 142 {ECO:0000269|PubMed:10611383}, 143
CC {ECO:0000269|PubMed:10611383}, 159 {ECO:0000269|PubMed:10611383}, 162
CC {ECO:0000269|PubMed:10611383}, 171 {ECO:0000269|PubMed:10611383}, 172
CC {ECO:0000269|PubMed:10611383}, 184 {ECO:0000269|PubMed:10611383}, 185
CC {ECO:0000269|PubMed:10611383}, 189 {ECO:0000269|PubMed:10611383}, 190
CC {ECO:0000269|PubMed:10611383};
CC -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
CC -!- CAUTION: Was originally (PubMed:18299247) thought to belong to the ABC
CC transporter family. Lacks the conserved ABC domain, which is one of the
CC features of the ABC transporter family. {ECO:0000305|PubMed:18299247}.
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DR EMBL; Y08501; CAA69756.3; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_085482.1; NC_001284.2.
DR AlphaFoldDB; P93280; -.
DR BioGRID; 6; 1.
DR IntAct; P93280; 1.
DR TCDB; 3.A.1.107.2; the atp-binding cassette (abc) superfamily.
DR PRIDE; P93280; -.
DR Araport; ATMG00110; -.
DR InParanoid; P93280; -.
DR OrthoDB; 1298332at2759; -.
DR PRO; PR:P93280; -.
DR Proteomes; UP000006548; Mitochondrion (cv. C24).
DR ExpressionAtlas; P93280; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR PANTHER; PTHR30070; PTHR30070; 1.
DR Pfam; PF03379; CcmB; 1.
PE 2: Evidence at transcript level;
KW Cytochrome c-type biogenesis; Membrane; Mitochondrion; Reference proteome;
KW RNA editing; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..206
FT /note="Putative cytochrome c biogenesis ccmB-like
FT mitochondrial protein"
FT /id="PRO_0000201549"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 23635 MW; B5CA91DBA2DC208F CRC64;
MRRLFFELYY KLIFSSTPIT SFSLFLLYIV VTPLMLGFEK DFLCHFHLGL IWISLLFSFL
SALFFRNEKE DGTLELYYLS TYCLPKILLL QLVGHWVIQI SCVFCGFPML QLLYQFGRSG
MDWLNILLGS LVLTLLCGIH SCLALGITSS SGWNSSQNLT TLPTLLPLTV FCTSIETEWF
HVLLLIGYFF LFVSLFPISV SISLQD
