CCMB_ECOLI
ID CCMB_ECOLI Reviewed; 220 AA.
AC P0ABL8; P33930; Q2MAP3;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Heme exporter protein B;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmB;
GN Name=ccmB; Synonyms=yejV; OrderedLocusNames=b2200, JW2188;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RT "Automated multiplex sequencing of the E.coli genome.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION, AND GENE NAME.
RX PubMed=7635817; DOI=10.1128/jb.177.15.4321-4326.1995;
RA Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.;
RT "Escherichia coli genes required for cytochrome c maturation.";
RL J. Bacteriol. 177:4321-4326(1995).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes.
CC -!- INTERACTION:
CC P0ABL8; P33931: ccmA; NbExp=2; IntAct=EBI-546936, EBI-6402796;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
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DR EMBL; U00008; AAA16392.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75260.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76663.1; -; Genomic_DNA.
DR PIR; F64989; F64989.
DR RefSeq; NP_416704.1; NC_000913.3.
DR RefSeq; WP_000971730.1; NZ_LN832404.1.
DR AlphaFoldDB; P0ABL8; -.
DR SMR; P0ABL8; -.
DR BioGRID; 4260485; 8.
DR ComplexPortal; CPX-3568; CcmABCDE system I cytochrome c biogenesis complex.
DR DIP; DIP-48046N; -.
DR IntAct; P0ABL8; 11.
DR STRING; 511145.b2200; -.
DR PaxDb; P0ABL8; -.
DR PRIDE; P0ABL8; -.
DR EnsemblBacteria; AAC75260; AAC75260; b2200.
DR EnsemblBacteria; BAE76663; BAE76663; BAE76663.
DR GeneID; 66673905; -.
DR GeneID; 946692; -.
DR KEGG; ecj:JW2188; -.
DR KEGG; eco:b2200; -.
DR PATRIC; fig|1411691.4.peg.36; -.
DR EchoBASE; EB1988; -.
DR eggNOG; COG2386; Bacteria.
DR HOGENOM; CLU_079069_1_0_6; -.
DR InParanoid; P0ABL8; -.
DR OMA; VKCLAHW; -.
DR PhylomeDB; P0ABL8; -.
DR BioCyc; EcoCyc:CCMB-MON; -.
DR BioCyc; MetaCyc:CCMB-MON; -.
DR PRO; PR:P0ABL8; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1903607; P:cytochrome c biosynthetic process; IDA:EcoCyc.
DR GO; GO:0017004; P:cytochrome complex assembly; IC:ComplexPortal.
DR GO; GO:1904334; P:heme import across plasma membrane; IC:ComplexPortal.
DR InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR InterPro; IPR026031; Cyt_c_CcmB_bac.
DR PANTHER; PTHR30070; PTHR30070; 1.
DR Pfam; PF03379; CcmB; 1.
DR PIRSF; PIRSF002764; CcmB; 1.
DR TIGRFAMs; TIGR01190; ccmB; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..220
FT /note="Heme exporter protein B"
FT /id="PRO_0000201539"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..44
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..127
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..192
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 23619 MW; 8DC1EEB8168401A3 CRC64;
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA PGIIWVAALL
SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH WMVTGLPLLI LSPLVAMLLG
MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL TVGLKRGGVL LSILVLPLTI PLLIFATAAM
DAASMHLPVD GYLAILGALL AGTATLSPFA TAAALRISIQ
