ID   CCMB_HAEIN              Reviewed;         221 AA.
AC   P45033;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Heme exporter protein B;
DE   AltName: Full=Cytochrome c-type biogenesis protein CcmB;
GN   Name=ccmB; OrderedLocusNames=HI_1090;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22747.1; -; Genomic_DNA.
DR   PIR; F64166; F64166.
DR   RefSeq; NP_439247.1; NC_000907.1.
DR   RefSeq; WP_005637214.1; NC_000907.1.
DR   AlphaFoldDB; P45033; -.
DR   STRING; 71421.HI_1090; -.
DR   EnsemblBacteria; AAC22747; AAC22747; HI_1090.
DR   GeneID; 56957430; -.
DR   KEGG; hin:HI_1090; -.
DR   PATRIC; fig|71421.8.peg.1135; -.
DR   eggNOG; COG2386; Bacteria.
DR   HOGENOM; CLU_079069_1_0_6; -.
DR   OMA; VKCLAHW; -.
DR   PhylomeDB; P45033; -.
DR   BioCyc; HINF71421:G1GJ1-1125-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR   InterPro; IPR026031; Cyt_c_CcmB_bac.
DR   PANTHER; PTHR30070; PTHR30070; 1.
DR   Pfam; PF03379; CcmB; 1.
DR   PIRSF; PIRSF002764; CcmB; 1.
DR   TIGRFAMs; TIGR01190; ccmB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..221
FT                   /note="Heme exporter protein B"
FT                   /id="PRO_0000201542"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  23644 MW;  2FF8EAFDC5228EF8 CRC64;
     MIFLEIIKRE LQIAMRKNAE ILNPLWFFLL VITLFPLVIG PDPKLLSRIA PGIAWVAALL
     SALLSFERLF RDDFIDGSLE QLMLTAQPLP MTALAKVVAH WLLTGLPLIL LSPIAALLLS
     LEVNIWWALV LTLLLGTPVL SCIGAIGVAL TVGLRKGGVL LSLLVVPLFI PVLIFASSVL
     EAAGLNVPYG GQLAILGAMM VGAVTLSPFA IAAALRISLD N