ID   CCMB_PARDP              Reviewed;         218 AA.
AC   P52219; A1B1W9;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Heme exporter protein B;
DE   AltName: Full=Cytochrome c-type biogenesis protein CcmB;
GN   Name=ccmB; OrderedLocusNames=Pden_1412;
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=318586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9043133; DOI=10.1099/00221287-143-2-563;
RA   Page D., Pearce D.A., Norris H.A., Ferguson S.J.;
RT   "The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing,
RT   and analysis of the potential of their products to form a haem or apo-c-
RT   type cytochrome transporter.";
RL   Microbiology 143:563-576(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
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DR   EMBL; Z71971; CAA96494.1; -; Genomic_DNA.
DR   EMBL; CP000489; ABL69513.1; -; Genomic_DNA.
DR   RefSeq; WP_011747731.1; NC_008686.1.
DR   AlphaFoldDB; P52219; -.
DR   STRING; 318586.Pden_1412; -.
DR   EnsemblBacteria; ABL69513; ABL69513; Pden_1412.
DR   KEGG; pde:Pden_1412; -.
DR   eggNOG; COG2386; Bacteria.
DR   HOGENOM; CLU_079069_1_0_5; -.
DR   OMA; VKCLAHW; -.
DR   Proteomes; UP000000361; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR   InterPro; IPR026031; Cyt_c_CcmB_bac.
DR   PANTHER; PTHR30070; PTHR30070; 1.
DR   Pfam; PF03379; CcmB; 1.
DR   PIRSF; PIRSF002764; CcmB; 1.
DR   TIGRFAMs; TIGR01190; ccmB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..218
FT                   /note="Heme exporter protein B"
FT                   /id="PRO_0000201545"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        41
FT                   /note="G -> A (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="L -> V (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        49
FT                   /note="Missing (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        98
FT                   /note="H -> D (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123
FT                   /note="A -> R (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        140
FT                   /note="M -> V (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        143
FT                   /note="A -> S (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159
FT                   /note="L -> V (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206..208
FT                   /note="PFA -> F (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213..214
FT                   /note="LR -> AS (in Ref. 1; CAA96494)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   218 AA;  22304 MW;  A94E6AA1237CAFBE CRC64;
     MKALLIRDLR LATRAGGGFG LALAFFLIVC TLVPFGVGPE GGTLSRIAPG ILWVGALLSC
     LLSLDRIFAL DFEDGSLDLL ATAPLPLEGA VAIKALAHWL VTGLPLALSA PVFGLLLHLP
     GPAYPWLVAS LLLGTPALSM LGAFGAAVTV GLRRGGLLLS LLVLPLYVPT LIFGAEAVRR
     GAAGADPMTA LVFLAAITLA TLALAPFAAA AALRVNLR