1A1L2_HUMAN
ID 1A1L2_HUMAN Reviewed; 568 AA.
AC Q4AC99;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2;
DE Short=ACC synthase-like protein 2;
GN Name=ACCSL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-529.
RA Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT "Identification of novel human genes predicted by combining multiple gene-
RT finders.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000305}.
CC -!- CAUTION: While belonging to the class-I pyridoxal-phosphate-dependent
CC aminotransferase family, it lacks a number of residues which are
CC necessary for activity thus suggesting that it lacks enzymatic
CC activity. {ECO:0000305}.
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DR EMBL; AB231734; BAE17132.1; -; mRNA.
DR EMBL; AC134775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS41636.1; -.
DR RefSeq; NP_001027025.2; NM_001031854.2.
DR AlphaFoldDB; Q4AC99; -.
DR SMR; Q4AC99; -.
DR BioGRID; 133403; 1.
DR STRING; 9606.ENSP00000368109; -.
DR iPTMnet; Q4AC99; -.
DR PhosphoSitePlus; Q4AC99; -.
DR BioMuta; ACCSL; -.
DR DMDM; 296439453; -.
DR MassIVE; Q4AC99; -.
DR PaxDb; Q4AC99; -.
DR PeptideAtlas; Q4AC99; -.
DR PRIDE; Q4AC99; -.
DR Antibodypedia; 26088; 48 antibodies from 16 providers.
DR DNASU; 390110; -.
DR Ensembl; ENST00000378832.1; ENSP00000368109.1; ENSG00000205126.2.
DR GeneID; 390110; -.
DR KEGG; hsa:390110; -.
DR MANE-Select; ENST00000378832.1; ENSP00000368109.1; NM_001031854.2; NP_001027025.2.
DR UCSC; uc001mxw.1; human.
DR CTD; 390110; -.
DR GeneCards; ACCSL; -.
DR HGNC; HGNC:34391; ACCSL.
DR HPA; ENSG00000205126; Not detected.
DR neXtProt; NX_Q4AC99; -.
DR PharmGKB; PA164714805; -.
DR VEuPathDB; HostDB:ENSG00000205126; -.
DR eggNOG; KOG0256; Eukaryota.
DR GeneTree; ENSGT00940000162841; -.
DR HOGENOM; CLU_017584_1_3_1; -.
DR InParanoid; Q4AC99; -.
DR OMA; RRHTQAI; -.
DR OrthoDB; 1156861at2759; -.
DR PhylomeDB; Q4AC99; -.
DR TreeFam; TF354218; -.
DR PathwayCommons; Q4AC99; -.
DR SignaLink; Q4AC99; -.
DR BioGRID-ORCS; 390110; 9 hits in 1057 CRISPR screens.
DR ChiTaRS; ACCSL; human.
DR GenomeRNAi; 390110; -.
DR Pharos; Q4AC99; Tdark.
DR PRO; PR:Q4AC99; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q4AC99; protein.
DR Bgee; ENSG00000205126; Expressed in monocyte and 11 other tissues.
DR ExpressionAtlas; Q4AC99; baseline and differential.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IBA:GO_Central.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006520; P:cellular amino acid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
PE 2: Evidence at transcript level;
KW Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..568
FT /note="Probable inactive 1-aminocyclopropane-1-carboxylate
FT synthase-like protein 2"
FT /id="PRO_0000337057"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 395
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
FT VARIANT 529
FT /note="C -> R (in dbSNP:rs2074051)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_060626"
FT CONFLICT 192
FT /note="S -> R (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="F -> S (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="L -> P (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="L -> P (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="K -> E (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
FT CONFLICT 454
FT /note="C -> R (in Ref. 1; BAE17132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 65249 MW; 233FC638E76AC393 CRC64;
MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH
TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV
PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL
CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN
GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ
LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI
YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA
FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS
GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK
LAMRRFCDVL QEQKEALIVK QLEDAMRE
