CCMB_PSEAE
ID CCMB_PSEAE Reviewed; 223 AA.
AC Q9I3N6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Heme exporter protein B;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmB;
GN Name=ccmB; OrderedLocusNames=PA1476;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
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DR EMBL; AE004091; AAG04865.1; -; Genomic_DNA.
DR PIR; H83462; H83462.
DR RefSeq; NP_250167.1; NC_002516.2.
DR RefSeq; WP_003114289.1; NZ_QZGE01000005.1.
DR AlphaFoldDB; Q9I3N6; -.
DR STRING; 287.DR97_547; -.
DR PaxDb; Q9I3N6; -.
DR PRIDE; Q9I3N6; -.
DR DNASU; 880948; -.
DR EnsemblBacteria; AAG04865; AAG04865; PA1476.
DR GeneID; 880948; -.
DR KEGG; pae:PA1476; -.
DR PATRIC; fig|208964.12.peg.1527; -.
DR PseudoCAP; PA1476; -.
DR HOGENOM; CLU_079069_1_0_6; -.
DR InParanoid; Q9I3N6; -.
DR OMA; VKCLAHW; -.
DR PhylomeDB; Q9I3N6; -.
DR BioCyc; PAER208964:G1FZ6-1502-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR InterPro; IPR026031; Cyt_c_CcmB_bac.
DR PANTHER; PTHR30070; PTHR30070; 1.
DR Pfam; PF03379; CcmB; 1.
DR PIRSF; PIRSF002764; CcmB; 1.
DR TIGRFAMs; TIGR01190; ccmB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..223
FT /note="Heme exporter protein B"
FT /id="PRO_0000287761"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 223 AA; 23398 MW; 4AF6A4ADB443A3F1 CRC64;
MSNVFSLLLA REARLLFRRP AELANPLVFF AIVIALFPLA VGPESQLLQT LSPGLVWVAA
LLAVLLSLEG LFRSDFEDGS MEQWVLSPHP LALLVLAKVL AHWLFSGLAL VLMSPLFALM
LGLPARCIPV LLLSLLLGTP VLSLLGAVGA ALTVGLKRGG LLLALLILPL YIPVLILGSG
ALQASLQGLP SSGHLLWLAS LTALALTLTP FAIAAGLKIS VGE
