CCMB_SHIFL
ID CCMB_SHIFL Reviewed; 220 AA.
AC Q83QV3;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Heme exporter protein B;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmB;
GN Name=ccmB; OrderedLocusNames=SF2284, S2414;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CcmB/CycW/HelB family. {ECO:0000305}.
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DR EMBL; AE005674; AAN43803.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17620.1; -; Genomic_DNA.
DR RefSeq; NP_708096.1; NC_004337.2.
DR AlphaFoldDB; Q83QV3; -.
DR SMR; Q83QV3; -.
DR STRING; 198214.SF2284; -.
DR EnsemblBacteria; AAN43803; AAN43803; SF2284.
DR EnsemblBacteria; AAP17620; AAP17620; S2414.
DR GeneID; 1025449; -.
DR KEGG; sfl:SF2284; -.
DR KEGG; sfx:S2414; -.
DR PATRIC; fig|198214.7.peg.2735; -.
DR HOGENOM; CLU_079069_1_0_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR003544; Cyt_c_biogenesis_CcmB.
DR InterPro; IPR026031; Cyt_c_CcmB_bac.
DR PANTHER; PTHR30070; PTHR30070; 1.
DR Pfam; PF03379; CcmB; 1.
DR PIRSF; PIRSF002764; CcmB; 1.
DR TIGRFAMs; TIGR01190; ccmB; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..220
FT /note="Heme exporter protein B"
FT /id="PRO_0000201543"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..44
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..127
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..192
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 190
FT /note="E -> D (in Ref. 2; AAP17620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 220 AA; 23633 MW; 9771EEB8168400B3 CRC64;
MMFWRIFRLE LRVAFRHSAE IANPLWFFLI VITLFPLSIG PEPQLLARIA PGIIWVAALL
SSLLALERLF RDDLQDGSLE QLMLLPLPLP AVVLAKVMAH WMVTGLPLLI LSPLVAMLLG
MDVYGWQVMA LTLLLGTPTL GFLGAPGVAL TVGLKRGGVL LSILVLPLTI PLLIFATAAM
DAASMHLPVE GYLAILGALL AGTATLSPFA TAAALRISIQ
