CCMC_ARATH
ID CCMC_ARATH Reviewed; 232 AA.
AC P92527; A7KNF3; Q6IDC1; Q8S883; Q8S8B9;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 4.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Putative cytochrome c biosynthesis ccmC-like mitochondrial protein;
DE AltName: Full=ABC transporter I family member 3;
DE Short=ABC transporter ABCI.3;
DE Short=AtABCI3;
GN Name=CCMC; Synonyms=ABCI3, ABCI4, ABCI5, CCB256, CCB3;
GN OrderedLocusNames=AtMg00900;
OS Arabidopsis thaliana (Mouse-ear cress).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. C24;
RX PubMed=8988169; DOI=10.1038/ng0197-57;
RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.;
RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in
RT 366,924 nucleotides.";
RL Nat. Genet. 15:57-61(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07681 AND AT2G07771).
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (AT2G07681 AND AT2G07771).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-232, AND RNA EDITING.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta; TISSUE=Rosette leaf;
RX PubMed=17565941; DOI=10.1534/genetics.107.073585;
RA Bentolila S., Elliott L.E., Hanson M.R.;
RT "Genetic architecture of mitochondrial editing in Arabidopsis thaliana.";
RL Genetics 178:1693-1708(2008).
RN [5]
RP RNA EDITING.
RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324;
RA Giege P., Brennicke A.;
RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in
RT ORFs.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be involved in the export of heme to the mitochondrion
CC for the biogenesis of c-type cytochromes.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=35 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 45 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 60 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 62 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 88 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 111 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 132 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 134 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 141 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 149 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 153 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 155 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 156 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 158 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 166 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 174 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 183 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 190 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 192 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 203 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 205 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 207 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 217 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 219 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 225 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}; Note=The stop codon at position 233 is
CC created by RNA editing.;
CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is
CC duplicated within the centromere of chromosome 2 resulting in the
CC duplication of the gene. The expression of the duplicated genes
CC (At2g07681 and At2g07771) is demonstrated.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
CC -!- CAUTION: Was originally (PubMed:18299247) thought to belong to the ABC
CC transporter family. Lacks the conserved ABC domain, which is one of the
CC features of the ABC transporter family. {ECO:0000305|PubMed:18299247}.
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DR EMBL; Y08501; CAA69832.3; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007143; AAM15415.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007730; AAM15509.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BT014752; AAT41735.1; ALT_SEQ; mRNA.
DR EMBL; BT014995; AAT70446.1; ALT_SEQ; mRNA.
DR EMBL; EF488896; ABS50608.1; ALT_SEQ; mRNA.
DR EMBL; EF488897; ABS50609.1; ALT_SEQ; mRNA.
DR RefSeq; NP_085546.2; NC_001284.2.
DR RefSeq; NP_973435.1; NM_201706.1.
DR AlphaFoldDB; P92527; -.
DR SMR; P92527; -.
DR PeptideAtlas; P92527; -.
DR PRIDE; P92527; -.
DR GeneID; 815357; -.
DR KEGG; ath:AT2G07771; -.
DR Araport; ATMG00900; -.
DR InParanoid; P92527; -.
DR OrthoDB; 1230200at2759; -.
DR PRO; PR:P92527; -.
DR Proteomes; UP000006548; Mitochondrion (cv. C24).
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
DR TIGRFAMs; TIGR01191; ccmC; 1.
PE 2: Evidence at transcript level;
KW Cytochrome c-type biogenesis; Membrane; Mitochondrion; Reference proteome;
KW RNA editing; Transmembrane; Transmembrane helix.
FT CHAIN 1..232
FT /note="Putative cytochrome c biosynthesis ccmC-like
FT mitochondrial protein"
FT /id="PRO_0000201561"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 184
FT /note="G -> S (in Ref. 2; AAM15415)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 26087 MW; 14B7ECE8A50AFA5D CRC64;
MSVSLLQPSF LMSKTRSYAQ ILIGSWLFLT AMAIYLSLGV APLDFQQGGN SRILYVHVPV
AWMSIIVYIA TAINTFLFLL TKHPLYLCSS GTGIEMGAFF TLFTLVTGGF WGRPMWGTFW
VWDARLTSVF ILFFIYLGAL CFQKLPVELA SILICVGLID IPIIKFSVNW WNTLHQPGSI
SRFGTSIHVS MLIPILSNFA NFLFLTCILF VLETRLLILS FLESSITEEI EA
