ID   CCMC_BRADU              Reviewed;         263 AA.
AC   P30962;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Heme exporter protein C;
DE   AltName: Full=Cytochrome c-type biogenesis protein CycZ;
GN   Name=cycZ; Synonyms=ccmC; OrderedLocusNames=blr0469;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 110RIF15;
RX   PubMed=1850420; DOI=10.1016/s0021-9258(20)89520-9;
RA   Ramseier T.M., Winteler H.V., Hennecke H.;
RT   "Discovery and sequence analysis of bacterial genes involved in the
RT   biogenesis of c-type cytochromes.";
RL   J. Biol. Chem. 266:7793-7803(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
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DR   EMBL; M60874; AAA26194.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC45734.1; -; Genomic_DNA.
DR   PIR; C39741; C39741.
DR   RefSeq; NP_767109.1; NC_004463.1.
DR   RefSeq; WP_011083300.1; NZ_CP011360.1.
DR   AlphaFoldDB; P30962; -.
DR   SMR; P30962; -.
DR   STRING; 224911.27348717; -.
DR   TCDB; 9.B.14.2.2; the putative heme handling protein (hhp) family.
DR   EnsemblBacteria; BAC45734; BAC45734; BAC45734.
DR   GeneID; 64020328; -.
DR   KEGG; bja:blr0469; -.
DR   PATRIC; fig|224911.44.peg.9002; -.
DR   eggNOG; COG0755; Bacteria.
DR   HOGENOM; CLU_066538_2_1_5; -.
DR   InParanoid; P30962; -.
DR   OMA; FHVPMWF; -.
DR   PhylomeDB; P30962; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   PANTHER; PTHR30071; PTHR30071; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   PRINTS; PR01386; CCMCBIOGNSIS.
DR   TIGRFAMs; TIGR01191; ccmC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..263
FT                   /note="Heme exporter protein C"
FT                   /id="PRO_0000201556"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  28831 MW;  A02EF75769F94EC0 CRC64;
     MTLIDLANPT RFLALTARVL PWLAAATVIL LAIGLYQSAL APDDYQQGAT VKIMFIHVPN
     AWLSMFVWGV MSIASLGTLV WRHPLADVAA KAAAPIGAAF TFLALLTGSL WGRPMWGTYW
     EWDARLTSVL ILFLMYLGLM ALWRAVDDPS RAARAAAVLT LVGAINLPII KFSVDWWNTL
     HQPASVMRMG GSSLDKSFLI PLLVMAIAFT LLFVTLHLAA MRNEILRRRV RSLQMMQASR
     MAFSSEMGAG SRQNNASNEV GAA