CCMC_ECOLI
ID CCMC_ECOLI Reviewed; 245 AA.
AC P0ABM1; P33929; Q2MAP4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Heme exporter protein C;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmC;
GN Name=ccmC; Synonyms=yejT, yejU; OrderedLocusNames=b2199, JW2187;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SEQUENCE REVISION, CHARACTERIZATION, AND GENE NAME.
RX PubMed=7635817; DOI=10.1128/jb.177.15.4321-4326.1995;
RA Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.;
RT "Escherichia coli genes required for cytochrome c maturation.";
RL J. Bacteriol. 177:4321-4326(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes.
CC -!- INTERACTION:
CC P0ABM1; P33931: ccmA; NbExp=4; IntAct=EBI-2123469, EBI-6402796;
CC P0ABM1; P0ABM5: ccmD; NbExp=4; IntAct=EBI-2123469, EBI-3894922;
CC P0ABM1; P69490: ccmE; NbExp=7; IntAct=EBI-2123469, EBI-1128007;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA16391.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U00008; AAA16391.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAC75259.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76662.1; -; Genomic_DNA.
DR PIR; E64989; E64989.
DR RefSeq; NP_416703.1; NC_000913.3.
DR RefSeq; WP_001295447.1; NZ_STEB01000002.1.
DR AlphaFoldDB; P0ABM1; -.
DR BioGRID; 4263174; 20.
DR BioGRID; 851044; 1.
DR ComplexPortal; CPX-3568; CcmABCDE system I cytochrome c biogenesis complex.
DR IntAct; P0ABM1; 4.
DR MINT; P0ABM1; -.
DR STRING; 511145.b2199; -.
DR TCDB; 9.B.14.2.3; the putative heme handling protein (hhp) family.
DR PaxDb; P0ABM1; -.
DR PRIDE; P0ABM1; -.
DR EnsemblBacteria; AAC75259; AAC75259; b2199.
DR EnsemblBacteria; BAE76662; BAE76662; BAE76662.
DR GeneID; 67416635; -.
DR GeneID; 946703; -.
DR KEGG; ecj:JW2187; -.
DR KEGG; eco:b2199; -.
DR PATRIC; fig|1411691.4.peg.37; -.
DR EchoBASE; EB1987; -.
DR eggNOG; COG0755; Bacteria.
DR HOGENOM; CLU_066538_2_0_6; -.
DR InParanoid; P0ABM1; -.
DR OMA; FHVPMWF; -.
DR PhylomeDB; P0ABM1; -.
DR BioCyc; EcoCyc:CCMC-MON; -.
DR BioCyc; MetaCyc:CCMC-MON; -.
DR PRO; PR:P0ABM1; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0020037; F:heme binding; IDA:EcoCyc.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1903607; P:cytochrome c biosynthetic process; IMP:EcoCyc.
DR GO; GO:0017004; P:cytochrome complex assembly; IC:ComplexPortal.
DR GO; GO:1904334; P:heme import across plasma membrane; IC:ComplexPortal.
DR GO; GO:0017003; P:protein-heme linkage; IDA:EcoCyc.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
DR TIGRFAMs; TIGR01191; ccmC; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..245
FT /note="Heme exporter protein C"
FT /id="PRO_0000201551"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..63
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..128
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..205
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 245 AA; 27885 MW; A98F2F754948EA60 CRC64;
MWKTLHQLAI PPRLYQICGW FIPWLAIASV VVLTVGWIWG FGFAPADYQQ GNSYRIIYLH
VPAAIWSMGI YASMAVAAFI GLVWQMKMAN LAVAAMAPIG AVFTFIALVT GSAWGKPMWG
TWWVWDARLT SELVLLFLYV GVIALWHAFD DRRLAGRAAG ILVLIGVVNL PIIHYSVEWW
NTLHQGSTRM QQSIDPAMRS PLRWSIFGFL LLSATLTLMR MRNLILLMEK RRPWVSELIL
KRGRK
