CCMC_HAEIN
ID CCMC_HAEIN Reviewed; 246 AA.
AC P45034;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Heme exporter protein C;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmC;
GN Name=ccmC; OrderedLocusNames=HI_1091;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
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DR EMBL; L42023; AAC22748.1; -; Genomic_DNA.
DR PIR; G64166; G64166.
DR RefSeq; NP_439248.1; NC_000907.1.
DR RefSeq; WP_005693415.1; NC_000907.1.
DR AlphaFoldDB; P45034; -.
DR SMR; P45034; -.
DR STRING; 71421.HI_1091; -.
DR EnsemblBacteria; AAC22748; AAC22748; HI_1091.
DR KEGG; hin:HI_1091; -.
DR PATRIC; fig|71421.8.peg.1136; -.
DR eggNOG; COG0755; Bacteria.
DR HOGENOM; CLU_066538_2_0_6; -.
DR OMA; FHVPMWF; -.
DR PhylomeDB; P45034; -.
DR BioCyc; HINF71421:G1GJ1-1126-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
DR TIGRFAMs; TIGR01191; ccmC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..246
FT /note="Heme exporter protein C"
FT /id="PRO_0000201555"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 246 AA; 27716 MW; 8CAACF95E74B1945 CRC64;
MWKWLHPYAK PETQYRICGK LSPLFAFLTL VLLGVGIVWG LAFAPADYQQ GNSFRIMYVH
APTAIWSMGV YGSMAIAAVV ALVWQIKQAH LAMIAMAPIG ALFTFLSLVT GAIWGKPMWG
TWWVWDARLT AELILFFLYL GILALYSAFS DRNIGAKAAG ILCITTVVIL PIIHFSVEWW
NTLHQGASIT KLEKPSIAIP MLVPLILCIF GFLTLYIWLT LVRYRMELLK EDAKRPWVKA
LAQTLK
