ID   CCMC_PARDP              Reviewed;         241 AA.
AC   P52220; A1B1W8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Heme exporter protein C;
DE   AltName: Full=Cytochrome c-type biogenesis protein CcmC;
GN   Name=ccmC; OrderedLocusNames=Pden_1411;
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=318586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9043133; DOI=10.1099/00221287-143-2-563;
RA   Page D., Pearce D.A., Norris H.A., Ferguson S.J.;
RT   "The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing,
RT   and analysis of the potential of their products to form a haem or apo-c-
RT   type cytochrome transporter.";
RL   Microbiology 143:563-576(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
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DR   EMBL; Z71971; CAA96495.1; -; Genomic_DNA.
DR   EMBL; CP000489; ABL69512.1; -; Genomic_DNA.
DR   RefSeq; WP_011747730.1; NC_008686.1.
DR   AlphaFoldDB; P52220; -.
DR   SMR; P52220; -.
DR   STRING; 318586.Pden_1411; -.
DR   PRIDE; P52220; -.
DR   EnsemblBacteria; ABL69512; ABL69512; Pden_1411.
DR   KEGG; pde:Pden_1411; -.
DR   eggNOG; COG0755; Bacteria.
DR   HOGENOM; CLU_066538_2_1_5; -.
DR   OMA; FHVPMWF; -.
DR   Proteomes; UP000000361; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   PANTHER; PTHR30071; PTHR30071; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   PRINTS; PR01386; CCMCBIOGNSIS.
DR   TIGRFAMs; TIGR01191; ccmC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..241
FT                   /note="Heme exporter protein C"
FT                   /id="PRO_0000201557"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        14..15
FT                   /note="RT -> SA (in Ref. 1; CAA96495)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        185..197
FT                   /note="ASLSMAPGERMAA -> PRCAWRQASAWRP (in Ref. 1;
FT                   CAA96495)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        228
FT                   /note="R -> A (in Ref. 1; CAA96495)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   241 AA;  26922 MW;  97B70DD008BA959E CRC64;
     MSIWEYANPV KFMRTSGAIL PWVVAGAAAC TVTGLVWGFL TPEDYKQGAT VKIIFLHVPA
     ALMAINIWLM MLVTSLIWLI RRHHVSALAA KAAAPVGAVM TLIALITGAI WGQPMWGTWW
     EWDPRLTSFL ILFLFYLGYM ALWEAVENPD SAADLTGVLC LVGSVFALLS RYAVNFWNQG
     LHQGASLSMA PGERMAAVYR YPLYLTMAGF FLLFLALLLI RTRTEIRRRR LAALLARENR
     A