CCMC_PSEAE
ID CCMC_PSEAE Reviewed; 252 AA.
AC Q9I3N5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Heme exporter protein C;
DE AltName: Full=Cytochrome c-type biogenesis protein CcmC;
GN Name=ccmC; OrderedLocusNames=PA1477;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004091; AAG04866.1; -; Genomic_DNA.
DR PIR; F83459; F83459.
DR RefSeq; NP_250168.1; NC_002516.2.
DR RefSeq; WP_003083135.1; NZ_QZGE01000005.1.
DR AlphaFoldDB; Q9I3N5; -.
DR SMR; Q9I3N5; -.
DR STRING; 287.DR97_546; -.
DR TCDB; 9.B.14.2.4; the putative heme handling protein (hhp) family.
DR PaxDb; Q9I3N5; -.
DR DNASU; 881087; -.
DR EnsemblBacteria; AAG04866; AAG04866; PA1477.
DR GeneID; 881087; -.
DR KEGG; pae:PA1477; -.
DR PATRIC; fig|208964.12.peg.1528; -.
DR PseudoCAP; PA1477; -.
DR HOGENOM; CLU_066538_2_0_6; -.
DR InParanoid; Q9I3N5; -.
DR OMA; FHVPMWF; -.
DR PhylomeDB; Q9I3N5; -.
DR BioCyc; PAER208964:G1FZ6-1503-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004096; F:catalase activity; IMP:PseudoCAP.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071978; P:bacterial-type flagellum-dependent swarming motility; IMP:PseudoCAP.
DR GO; GO:0071977; P:bacterial-type flagellum-dependent swimming motility; IMP:PseudoCAP.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IMP:PseudoCAP.
DR GO; GO:0002049; P:pyoverdine biosynthetic process; IMP:PseudoCAP.
DR GO; GO:0043107; P:type IV pilus-dependent motility; IMP:PseudoCAP.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
DR TIGRFAMs; TIGR01191; ccmC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..252
FT /note="Heme exporter protein C"
FT /id="PRO_0000287762"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 252 AA; 28289 MW; 2695CEBE46FEB56C CRC64;
MMNWTWFHKL GSPKWFYEIS GRWLPWFAVA AALLIVTGCV WGLAFAPPDY QQGNSFRIIY
IHVPAAFLAQ SCYVMLAVAG AVGLIWKMKI ADVAVQCAAP IGAWMTFVAL LTGAVWGKPT
WGAWWVWDAR LTAMLILLFL YFGIIALGQA ISNRDSAAKA CAVLAIVGVV NIPIIKYSVE
WWNTLHQPAT FTITEKPAMP VEMWLPLLIM VLGFYCFFAA MLLVRMRLEV LKRESRTAWA
KAEVKALVEK AR
