ID   CCMD_ECOLI              Reviewed;          69 AA.
AC   P0ABM5; P36770; Q2MAP5;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Heme exporter protein D;
DE   AltName: Full=Cytochrome c-type biogenesis protein CcmD;
GN   Name=ccmD; Synonyms=yojM; OrderedLocusNames=b2198, JW2186;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / BHB2600;
RA   Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA   Church G.M.;
RL   Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   IDENTIFICATION.
RA   Robison K.;
RL   Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   CHARACTERIZATION, AND GENE NAME.
RX   PubMed=7635817; DOI=10.1128/jb.177.15.4321-4326.1995;
RA   Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.;
RT   "Escherichia coli genes required for cytochrome c maturation.";
RL   J. Bacteriol. 177:4321-4326(1995).
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000305}.
CC   -!- INTERACTION:
CC       P0ABM5; P0ABM1: ccmC; NbExp=4; IntAct=EBI-3894922, EBI-2123469;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmD/CycX/HelD family. {ECO:0000305}.
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DR   EMBL; U00008; AAA16390.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75258.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76661.1; -; Genomic_DNA.
DR   PIR; D64989; D64989.
DR   RefSeq; NP_416702.1; NC_000913.3.
DR   RefSeq; WP_000186540.1; NZ_STEB01000002.1.
DR   AlphaFoldDB; P0ABM5; -.
DR   SMR; P0ABM5; -.
DR   BioGRID; 4260484; 9.
DR   ComplexPortal; CPX-3568; CcmABCDE system I cytochrome c biogenesis complex.
DR   IntAct; P0ABM5; 2.
DR   STRING; 511145.b2198; -.
DR   PaxDb; P0ABM5; -.
DR   EnsemblBacteria; AAC75258; AAC75258; b2198.
DR   EnsemblBacteria; BAE76661; BAE76661; BAE76661.
DR   GeneID; 67416634; -.
DR   GeneID; 946709; -.
DR   KEGG; ecj:JW2186; -.
DR   KEGG; eco:b2198; -.
DR   PATRIC; fig|511145.12.peg.2287; -.
DR   EchoBASE; EB2088; -.
DR   eggNOG; COG3114; Bacteria.
DR   HOGENOM; CLU_180892_0_0_6; -.
DR   OMA; MFFQSWS; -.
DR   PhylomeDB; P0ABM5; -.
DR   BioCyc; EcoCyc:EG12169-MON; -.
DR   BioCyc; MetaCyc:EG12169-MON; -.
DR   PRO; PR:P0ABM5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IC:ComplexPortal.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR   GO; GO:1903607; P:cytochrome c biosynthetic process; IDA:EcoCyc.
DR   GO; GO:0017004; P:cytochrome complex assembly; IC:ComplexPortal.
DR   GO; GO:1904334; P:heme import across plasma membrane; IC:ComplexPortal.
DR   InterPro; IPR007078; Haem_export_protD_CcmD.
DR   Pfam; PF04995; CcmD; 1.
DR   TIGRFAMs; TIGR03141; cytochro_ccmD; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..69
FT                   /note="Heme exporter protein D"
FT                   /id="PRO_0000201563"
FT   TRANSMEM        18..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   69 AA;  7745 MW;  BEC1D341EEADA018 CRC64;
     MTPAFASWNE FFAMGGYAFF VWLAVVMTVI PLVVLVVHSV MQHRAILRGV AQQRAREARL
     RAAQQQEAA