ID   CCMD_SHIFL              Reviewed;          69 AA.
AC   P0ABM8; P36770;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Heme exporter protein D;
DE   AltName: Full=Cytochrome c-type biogenesis protein CcmD;
GN   Name=ccmD; OrderedLocusNames=SF2282, S2412;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Required for the export of heme to the periplasm for the
CC       biogenesis of c-type cytochromes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmD/CycX/HelD family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43801.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17618.1; -; Genomic_DNA.
DR   RefSeq; NP_708094.1; NC_004337.2.
DR   RefSeq; WP_000186540.1; NZ_WPGW01000022.1.
DR   AlphaFoldDB; P0ABM8; -.
DR   SMR; P0ABM8; -.
DR   STRING; 198214.SF2282; -.
DR   EnsemblBacteria; AAN43801; AAN43801; SF2282.
DR   EnsemblBacteria; AAP17618; AAP17618; S2412.
DR   GeneID; 1027291; -.
DR   GeneID; 67416634; -.
DR   KEGG; sfl:SF2282; -.
DR   KEGG; sfx:S2412; -.
DR   PATRIC; fig|198214.7.peg.2733; -.
DR   HOGENOM; CLU_180892_0_0_6; -.
DR   OMA; MFFQSWS; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   GO; GO:0015886; P:heme transport; IEA:InterPro.
DR   InterPro; IPR007078; Haem_export_protD_CcmD.
DR   Pfam; PF04995; CcmD; 1.
DR   TIGRFAMs; TIGR03141; cytochro_ccmD; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..69
FT                   /note="Heme exporter protein D"
FT                   /id="PRO_0000201566"
FT   TRANSMEM        18..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   69 AA;  7745 MW;  BEC1D341EEADA018 CRC64;
     MTPAFASWNE FFAMGGYAFF VWLAVVMTVI PLVVLVVHSV MQHRAILRGV AQQRAREARL
     RAAQQQEAA