CCME_SALTY
ID CCME_SALTY Reviewed; 159 AA.
AC Q8XG35;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Cytochrome c maturation protein E {ECO:0000255|HAMAP-Rule:MF_01959};
DE AltName: Full=Heme chaperone CcmE {ECO:0000255|HAMAP-Rule:MF_01959};
GN Name=ccmE1 {ECO:0000255|HAMAP-Rule:MF_01959};
GN Synonyms=cycJ1 {ECO:0000255|HAMAP-Rule:MF_01959};
GN OrderedLocusNames=STM2250;
GN and
GN Name=ccmE2 {ECO:0000255|HAMAP-Rule:MF_01959};
GN Synonyms=cycJ2 {ECO:0000255|HAMAP-Rule:MF_01959};
GN OrderedLocusNames=STM3815;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Heme chaperone required for the biogenesis of c-type
CC cytochromes. Transiently binds heme delivered by CcmC and transfers the
CC heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
CC {ECO:0000255|HAMAP-Rule:MF_01959}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01959}; Single-pass type II membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01959}; Periplasmic side {ECO:0000255|HAMAP-
CC Rule:MF_01959}.
CC -!- SIMILARITY: Belongs to the CcmE/CycJ family. {ECO:0000255|HAMAP-
CC Rule:MF_01959}.
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DR EMBL; AE006468; AAL22674.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21152.1; -; Genomic_DNA.
DR RefSeq; NP_461193.1; NC_003197.2.
DR RefSeq; NP_462715.1; NC_003197.2.
DR RefSeq; WP_001053618.1; NC_003197.2.
DR AlphaFoldDB; Q8XG35; -.
DR SMR; Q8XG35; -.
DR STRING; 99287.STM2250; -.
DR PaxDb; Q8XG35; -.
DR EnsemblBacteria; AAL21152; AAL21152; STM2250.
DR EnsemblBacteria; AAL22674; AAL22674; STM3815.
DR GeneID; 1253772; -.
DR GeneID; 1255342; -.
DR KEGG; stm:STM2250; -.
DR KEGG; stm:STM3815; -.
DR PATRIC; fig|99287.12.peg.2384; -.
DR HOGENOM; CLU_079503_1_0_6; -.
DR OMA; HVEFAVH; -.
DR PhylomeDB; Q8XG35; -.
DR BioCyc; SENT99287:STM3815-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR GO; GO:0017003; P:protein-heme linkage; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_01959; CcmE; 1.
DR InterPro; IPR004329; CcmE.
DR InterPro; IPR036127; CcmE-like_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR34128; PTHR34128; 1.
DR Pfam; PF03100; CcmE; 1.
DR SUPFAM; SSF82093; SSF82093; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Heme;
KW Iron; Membrane; Metal-binding; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..159
FT /note="Cytochrome c-type biogenesis protein CcmE"
FT /id="PRO_0000238863"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01959"
FT TRANSMEM 9..29
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01959"
FT TOPO_DOM 30..159
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01959"
FT REGION 129..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 130
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01959"
FT BINDING 134
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01959"
SQ SEQUENCE 159 AA; 17688 MW; 648DACEB45E065E3 CRC64;
MNLRRKNRLW VVCAVLAGLG LTTALVLYAL RANIDLFYTP GEILYGKRET QQLPAAGQRL
RVGGMVMPGS VRRDPDSLKV NFSLYDAEGS VTVSYEGILP DLFREGQGVV VQGTLEKGNH
VLAHEVLAKH DENYTPPEVE KAMQENHRRP QRADKDTSS
