CCMF1_ARATH
ID CCMF1_ARATH Reviewed; 382 AA.
AC Q9T6H8; A7KNF5; O03601; Q1ZXZ2; Q31706;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Cytochrome c biogenesis CcmF N-terminal-like mitochondrial protein 1 {ECO:0000305};
DE AltName: Full=Cytochrome c biogenesis orf382 {ECO:0000312|EMBL:CAA69825.3};
GN Name=CCMFN1 {ECO:0000303|PubMed:18644794};
GN Synonyms=CC6BN1, CCB382 {ECO:0000312|EMBL:CAA69825.3};
GN OrderedLocusNames=AtMg00830 {ECO:0000312|Araport:ATMG00830};
GN and
GN OrderedLocusNames=At2g07783 {ECO:0000312|Araport:AT2G07783};
OS Arabidopsis thaliana (Mouse-ear cress).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. C24;
RA Schuster W.;
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. C24;
RX PubMed=8988169; DOI=10.1038/ng0197-57;
RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.;
RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in
RT 366,924 nucleotides.";
RL Nat. Genet. 15:57-61(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07783).
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION (AT2G07783).
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-184, AND RNA EDITING.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta; TISSUE=Rosette leaf;
RX PubMed=17565941; DOI=10.1534/genetics.107.073585;
RA Bentolila S., Elliott L.E., Hanson M.R.;
RT "Genetic architecture of mitochondrial editing in Arabidopsis thaliana.";
RL Genetics 178:1693-1708(2008).
RN [6]
RP RNA EDITING.
RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324;
RA Giege P., Brennicke A.;
RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in
RT ORFs.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999).
RN [7]
RP FUNCTION, INTERACTION WITH CCMFN2 AND CCMH, AND SUBCELLULAR LOCATION.
RX PubMed=18644794; DOI=10.1074/jbc.m802621200;
RA Rayapuram N., Hagenmuller J., Grienenberger J.M., Bonnard G., Giege P.;
RT "The three mitochondrial encoded CcmF proteins form a complex that
RT interacts with CCMH and c-type apocytochromes in Arabidopsis.";
RL J. Biol. Chem. 283:25200-25208(2008).
CC -!- FUNCTION: Forms a complex with CCMFC, CCMFN2 and CCMH that performs the
CC assembly of heme with c-type apocytochromes in mitochondria.
CC {ECO:0000269|PubMed:18644794}.
CC -!- SUBUNIT: Interacts with CCMFN2 and CCMH. {ECO:0000269|PubMed:18644794}.
CC -!- INTERACTION:
CC Q9T6H8; Q33884: CCMFN2; NbExp=5; IntAct=EBI-1797466, EBI-763400;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:18644794}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- RNA EDITING: Modified_positions=15 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 35 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 48 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 53 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 67 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 88 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 90 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 97 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 114 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 124 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 135 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 162 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 194 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 237 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 240 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 260 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 264 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 269 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941}, 319 {ECO:0000269|PubMed:10611383,
CC ECO:0000269|PubMed:17565941};
CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is
CC duplicated within the centromere of chromosome 2 resulting in the
CC duplication of the gene. The expression of the duplicated gene
CC (At2g07783) is not demonstrated. It is also probably not RNA edited and
CC therefore differs in all the positions known to be edited.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA66908.1; Type=Miscellaneous discrepancy; Note=Its N-terminal part is produced after trans-splicing. No experimental data confirms this assertion.; Evidence={ECO:0000305};
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DR EMBL; X98254; CAA66908.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Y08501; CAA69825.3; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC007730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EF488898; ABS50610.1; -; mRNA.
DR EMBL; EF488899; ABS50611.1; -; mRNA.
DR PIR; S71281; S71281.
DR RefSeq; NP_085539.2; NC_001284.2.
DR AlphaFoldDB; Q9T6H8; -.
DR IntAct; Q9T6H8; 3.
DR STRING; 3702.ATMG00830.1; -.
DR PaxDb; Q9T6H8; -.
DR PeptideAtlas; Q9T6H8; -.
DR PRIDE; Q9T6H8; -.
DR Araport; AT2G07783; -.
DR Araport; ATMG00830; -.
DR eggNOG; ENOG502QQ5D; Eukaryota.
DR InParanoid; Q9T6H8; -.
DR OrthoDB; 746605at2759; -.
DR PRO; PR:Q9T6H8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR Proteomes; UP000006548; Mitochondrion (cv. C24).
DR ExpressionAtlas; Q9T6H8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003567; Cyt_c_biogenesis.
DR InterPro; IPR003569; Cyt_c_biogenesis_plant.
DR PANTHER; PTHR43653; PTHR43653; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01410; CCBIOGENESIS.
DR PRINTS; PR01412; CCBSBIOGNSIS.
PE 1: Evidence at protein level;
KW Cytochrome c-type biogenesis; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; RNA editing;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..382
FT /note="Cytochrome c biogenesis CcmF N-terminal-like
FT mitochondrial protein 1"
FT /id="PRO_0000201594"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 382 AA; 43647 MW; 7B9100599199E244 CRC64;
MSISIYEFFH YSLFLGLFVA FTYNKKQPPA FGAALAFWCI LLSFLGLLFC HISNNLSNYN
VLTANALFFY QISGTWSNHE GSILLWCWIL NFYGFFFCYR GRPQSHNVLK QGGYRESLFF
FFVLNFVKNS ILSLLRYEQE SGLKNQLYTP FVLRTLVDSE LCSRRNRTFD GPALFYAPLY
PERKIKNPLD AWRFRGSREG KRTHPLLHLA RDDKERASSI DEQRIDGALG IALFFSFFLL
ASSDPFVRNF FVCTEPLAEL NPVLQDPILA IHPPCIYAGD VASAEGFGLC RSKMMNGIVA
LHSPPMRKDA AEKNGTLLCS AGCVGSRITS ELFTLKFKHV GAKCYPALLL RSNRSPLMLL
RRRFFAFSSF WAGARSHSTK RY
