ID   CCMF_HAEIN              Reviewed;         648 AA.
AC   P45037;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Cytochrome c-type biogenesis protein CcmF;
GN   Name=ccmF; OrderedLocusNames=HI_1094;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC       subunit of a heme lyase.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22751.1; -; Genomic_DNA.
DR   PIR; A64167; A64167.
DR   RefSeq; NP_439251.1; NC_000907.1.
DR   RefSeq; WP_005693418.1; NC_000907.1.
DR   AlphaFoldDB; P45037; -.
DR   SMR; P45037; -.
DR   STRING; 71421.HI_1094; -.
DR   EnsemblBacteria; AAC22751; AAC22751; HI_1094.
DR   KEGG; hin:HI_1094; -.
DR   PATRIC; fig|71421.8.peg.1139; -.
DR   eggNOG; COG1138; Bacteria.
DR   HOGENOM; CLU_015041_3_0_6; -.
DR   OMA; SYWGMQL; -.
DR   PhylomeDB; P45037; -.
DR   BioCyc; HINF71421:G1GJ1-1129-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR032523; CcmF_C.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR003567; Cyt_c_biogenesis.
DR   InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR   PANTHER; PTHR43653; PTHR43653; 1.
DR   Pfam; PF16327; CcmF_C; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   PRINTS; PR01410; CCBIOGENESIS.
DR   PRINTS; PR01411; CCMFBIOGNSIS.
DR   TIGRFAMs; TIGR00353; nrfE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..648
FT                   /note="Cytochrome c-type biogenesis protein CcmF"
FT                   /id="PRO_0000201584"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        616..636
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   648 AA;  72353 MW;  ABE434B80F4B92B6 CRC64;
     MIAELGNYAL ALSLAVSLML AIFPLWGAEK GNAQLMALAR PMTYGLFASL SIAFAALFYL
     FAVNDFSVQY IVNNSNTTLP IYYRLSAVWG SHEGSLLLWI WLLAVWSFAV ALLSKHLPQE
     AVARVLGIMG IISVGFVLFV LFTSNPFTRT FPDFPVDGKE LNPMLQDVGL IFHPPLLYMG
     YVGFSVAFAF AIASLMTGKL DSAWARWSRP WTLAAWVFLT LGIVLGSWWA YYELGWGGWW
     FWDPVENSSF MPWLAGTALI HSLSVTEKRG SFKAWTVLLA ILAFSLCLLG TFLVRSGILV
     SVHAFASDPT RGLYILAYLV VVIGGSLALY AYKGSQIRSR DNAERYSRES MLLLNNILLM
     TALCVVFLGT LLPLVHKQLG LGSISIGAPF FDQMFLIIMT PFALLLGIGP LVKWRRDQFS
     AIRTPVVICV FVMLIAGFAL PYFLQDKITV SSVLGSMMTV IIALLALYEL QQRATHRESF
     FVGVRKLSRS HWGMMLAHLG VAMTVWGIAF SQNFSVERDV RMKVGESAQI GRYDFKFTGV
     TDENGPNYIG GKAQIDISKD GQPEASLFAE KRFYTVSRMS MTEAAIAGGL TRDLYVALGE
     KLEDNSWALR LYYKPFIRWI WIGGLFMALG GLLCMFDRRY RFNVLLKK