ID   CCMG_PARDP              Reviewed;         179 AA.
AC   P52236; A1B1W7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Thiol:disulfide interchange protein DsbE homolog;
DE   AltName: Full=Cytochrome c biogenesis protein CcmG;
DE   Flags: Precursor;
GN   Name=ccmG; OrderedLocusNames=Pden_1410;
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=318586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9220005; DOI=10.1046/j.1365-2958.1997.4061775.x;
RA   Page M.D., Ferguson S.J.;
RT   "Paracoccus denitrificans CcmG is a periplasmic protein-disulphide
RT   oxidoreductase required for c- and aa3-type cytochrome biogenesis; evidence
RT   for a reductase role in vivo.";
RL   Mol. Microbiol. 24:977-990(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for disulfide bond formation in some periplasmic
CC       proteins. Also acts as a disulfide oxidoreductase in cytochromes c
CC       biogenesis. The cysteines of apocytochromes c must be in the reduced
CC       state for covalent linkage between the two moieties to occur.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. DsbE subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABL69511.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z71971; CAA96497.1; -; Genomic_DNA.
DR   EMBL; CP000489; ABL69511.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P52236; -.
DR   SMR; P52236; -.
DR   STRING; 318586.Pden_1410; -.
DR   PRIDE; P52236; -.
DR   EnsemblBacteria; ABL69511; ABL69511; Pden_1410.
DR   KEGG; pde:Pden_1410; -.
DR   eggNOG; COG0526; Bacteria.
DR   HOGENOM; CLU_042529_19_0_5; -.
DR   Proteomes; UP000000361; Chromosome 1.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR   CDD; cd03010; TlpA_like_DsbE; 1.
DR   InterPro; IPR004799; Periplasmic_diS_OxRdtase_DsbE.
DR   InterPro; IPR013740; Redoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF08534; Redoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR00385; dsbE; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Cytochrome c-type biogenesis; Disulfide bond; Periplasm;
KW   Redox-active center; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..179
FT                   /note="Thiol:disulfide interchange protein DsbE homolog"
FT                   /id="PRO_0000034285"
FT   DOMAIN          37..174
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        77..80
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   CONFLICT        28..29
FT                   /note="RD -> PN (in Ref. 1; CAA96497)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        61..62
FT                   /note="ML -> IV (in Ref. 1; CAA96497)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        145..146
FT                   /note="ID -> MH (in Ref. 1; CAA96497)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   179 AA;  19361 MW;  DC802F6D5ADFA400 CRC64;
     MARFSPMMLL PVAIFAGFAG LSGWALLRDD PDALPSAMIG REAPSVGEAT LPGKVQLTDE
     MLRQPGVKLV NFWASWCPPC RAEHPTLTEL SARLPVYGVD LKDPEGAALG FLSEHGDPFH
     ALAADPRGRV AIDWGVTAPP ETFIIDGSGR ILHRHAGPLV REDYTNRFLP ELEKALAAE