CCMH_ECOLI
ID CCMH_ECOLI Reviewed; 350 AA.
AC P0ABM9; P33925; Q2MAP9;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmH;
DE Flags: Precursor;
GN Name=ccmH; Synonyms=yejP; OrderedLocusNames=b2194, JW2182;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP CHARACTERIZATION, AND GENE NAME.
RX PubMed=7635817; DOI=10.1128/jb.177.15.4321-4326.1995;
RA Thoeny-Meyer L., Fischer F., Kunzler P., Ritz D., Hennecke H.;
RT "Escherichia coli genes required for cytochrome c maturation.";
RL J. Bacteriol. 177:4321-4326(1995).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: May be required for the biogenesis of c-type cytochromes.
CC Possible subunit of a heme lyase.
CC -!- INTERACTION:
CC P0ABM9; P33927: ccmF; NbExp=3; IntAct=EBI-560309, EBI-763370;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
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DR EMBL; U00008; AAA16386.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75254.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76657.1; -; Genomic_DNA.
DR PIR; H64988; H64988.
DR RefSeq; NP_416698.1; NC_000913.3.
DR RefSeq; WP_001211575.1; NZ_STEB01000002.1.
DR AlphaFoldDB; P0ABM9; -.
DR BMRB; P0ABM9; -.
DR SMR; P0ABM9; -.
DR BioGRID; 4260481; 13.
DR ComplexPortal; CPX-3569; CcmFH system I cytochrome c biogenesis complex.
DR DIP; DIP-48146N; -.
DR IntAct; P0ABM9; 5.
DR MINT; P0ABM9; -.
DR STRING; 511145.b2194; -.
DR jPOST; P0ABM9; -.
DR PaxDb; P0ABM9; -.
DR PRIDE; P0ABM9; -.
DR EnsemblBacteria; AAC75254; AAC75254; b2194.
DR EnsemblBacteria; BAE76657; BAE76657; BAE76657.
DR GeneID; 58388765; -.
DR GeneID; 946623; -.
DR KEGG; ecj:JW2182; -.
DR KEGG; eco:b2194; -.
DR PATRIC; fig|1411691.4.peg.42; -.
DR EchoBASE; EB1983; -.
DR eggNOG; COG3088; Bacteria.
DR eggNOG; COG4235; Bacteria.
DR HOGENOM; CLU_036074_0_0_6; -.
DR OMA; KIWFVSG; -.
DR PhylomeDB; P0ABM9; -.
DR BioCyc; EcoCyc:EG12052-MON; -.
DR BioCyc; MetaCyc:EG12052-MON; -.
DR PRO; PR:P0ABM9; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031237; C:intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015035; F:protein-disulfide reductase activity; ISM:EcoCyc.
DR GO; GO:0018063; P:cytochrome c-heme linkage; IDA:ComplexPortal.
DR GO; GO:0018378; P:cytochrome c-heme linkage via heme-L-cysteine; IBA:GO_Central.
DR GO; GO:0017004; P:cytochrome complex assembly; IMP:EcoCyc.
DR Gene3D; 1.10.8.640; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF03918; CcmH; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Heme;
KW Iron; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW TPR repeat; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..350
FT /note="Cytochrome c-type biogenesis protein CcmH"
FT /id="PRO_0000006612"
FT TOPO_DOM 19..96
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..350
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 222..255
FT /note="TPR 1"
FT REPEAT 293..326
FT /note="TPR 2"
FT BINDING 43
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
FT BINDING 46
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
SQ SEQUENCE 350 AA; 39089 MW; 002126A1F17F493F CRC64;
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS IADSNSMIAT
DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL TVLLWVLPVV AIGIGGWVIY
ARSRRRVRVV PEAFPEQSVP EGKRAGYVVY LPGIVVALIV AGVSYYQTGN YQQVKIWQQA
TAQAPALLDR ALDPKADPLN EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI
ATDAYATAYR LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRTDH SNIRVLSMYA
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
