ID   CCMH_HAEIN              Reviewed;         459 AA.
AC   P46458;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Putative cytochrome c-type biogenesis protein CcmH;
DE   Flags: Precursor;
GN   Name=ccmH; OrderedLocusNames=HI_1096;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: May be required for the biogenesis of c-type cytochromes.
CC       Possible subunit of a heme lyase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=L42023; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L42023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; P46458; -.
DR   PhylomeDB; P46458; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0018378; P:cytochrome c-heme linkage via heme-L-cysteine; IBA:GO_Central.
DR   Gene3D; 1.10.8.640; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR   InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR   InterPro; IPR017560; Cyt_c_biogenesis_CcmI.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF03918; CcmH; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR03142; cytochro_ccmI; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   5: Uncertain;
KW   Cytochrome c-type biogenesis; Heme; Iron; Metal-binding; Periplasm;
KW   Reference proteome; Repeat; Signal; TPR repeat.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..459
FT                   /note="Putative cytochrome c-type biogenesis protein CcmH"
FT                   /id="PRO_0000006613"
FT   REPEAT          322..355
FT                   /note="TPR 1"
FT   REPEAT          393..426
FT                   /note="TPR 2"
FT   BINDING         44
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255"
FT   BINDING         47
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  52516 MW;  C9362E35D2E3B143 CRC64;
     MKKTWLFLTA LLFSSVAFSA IDALNFSSPQ QESDYHQLTQ SLRCPQCQNN NIADSNATIA
     VDMRGKVFEL LQEGKSKNDV VDYMVARYGN FVTYDPPITA STLVLWIAPL LLVLLGVVFL
     LRRKPKTQSA VKSQEILTDE DNARLAELLN KDKXMNFTLI FILTTLVVAL ICFYPLLCQF
     KAKHGQKRDD LNKALYFSRL EEIEQDNSQG LVENVEQLKQ ELQKTLLDDV PSKVQENVDY
     SGKSYGKIWF ISGVLALGII AGPSYFMVGS WQAESMLEQT YAKLPYFFDR MKNEDKNPFS
     DTEMQQFSTA LRIDLQKNPT DAKKWWMLGQ IGMNLGDARL AFDSYQKANK LEPDNVQYKL
     GYARILMFSE DATDKLKGGN LLREVIRQEH TNIEALSLLA FRYFETEDYK MAAVTWAMML
     RLMPKDDERV PLIEKSIRTA RDALEAQNEE KSKSITPEK