ID   CCMH_PSEAE              Reviewed;         155 AA.
AC   Q9I3N0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Cytochrome c-type biogenesis protein CcmH;
DE   Flags: Precursor;
GN   Name=ccmH; OrderedLocusNames=PA1482;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC       subunit of a heme lyase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}; Periplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG04871.1; -; Genomic_DNA.
DR   PIR; C83460; C83460.
DR   RefSeq; NP_250173.1; NC_002516.2.
DR   RefSeq; WP_003114292.1; NZ_QZGE01000005.1.
DR   PDB; 2HL7; X-ray; 1.70 A; A=21-100.
DR   PDBsum; 2HL7; -.
DR   AlphaFoldDB; Q9I3N0; -.
DR   SMR; Q9I3N0; -.
DR   STRING; 287.DR97_541; -.
DR   PaxDb; Q9I3N0; -.
DR   PRIDE; Q9I3N0; -.
DR   DNASU; 881029; -.
DR   EnsemblBacteria; AAG04871; AAG04871; PA1482.
DR   GeneID; 881029; -.
DR   KEGG; pae:PA1482; -.
DR   PATRIC; fig|208964.12.peg.1533; -.
DR   PseudoCAP; PA1482; -.
DR   HOGENOM; CLU_107187_0_0_6; -.
DR   InParanoid; Q9I3N0; -.
DR   OMA; MIAADMR; -.
DR   PhylomeDB; Q9I3N0; -.
DR   BioCyc; PAER208964:G1FZ6-1508-MON; -.
DR   EvolutionaryTrace; Q9I3N0; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0018378; P:cytochrome c-heme linkage via heme-L-cysteine; IBA:GO_Central.
DR   Gene3D; 1.10.8.640; -; 1.
DR   InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR   InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR   Pfam; PF03918; CcmH; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytochrome c-type biogenesis; Heme; Iron; Membrane;
KW   Metal-binding; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..155
FT                   /note="Cytochrome c-type biogenesis protein CcmH"
FT                   /id="PRO_0000287765"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         45
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255"
FT   BINDING         48
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /note="covalent"
FT                   /evidence="ECO:0000255"
FT   HELIX           21..24
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   HELIX           30..42
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   STRAND          48..50
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   TURN            53..55
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   HELIX           59..74
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   HELIX           78..89
FT                   /evidence="ECO:0007829|PDB:2HL7"
FT   TURN            90..92
FT                   /evidence="ECO:0007829|PDB:2HL7"
SQ   SEQUENCE   155 AA;  17445 MW;  49E8C2A36E8E1B74 CRC64;
     MKRFLATALL GLALCGVARA AIDTYEFASD AERERFRNLT QELRCPKCQN QDIADSNAPI
     AADLRKQIYG QLQQGKSDGE IVDYMVARYG DFVRYKPPVN ERTWLLWFGP GALLLFGVLV
     IGVIVLRRRR TAAKVQTTLS AEEQARLANL LKNDK