CCMH_RHIME
ID CCMH_RHIME Reviewed; 151 AA.
AC P45406;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmH;
DE AltName: Full=Cytochrome c-type biogenesis protein CycL;
DE Flags: Precursor;
GN Name=ccmH; Synonyms=cycL; OrderedLocusNames=R01020; ORFNames=SMc02364;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AK631;
RX PubMed=7715602; DOI=10.1007/bf00425819;
RA Kereszt A., Slaska-Kiss K., Putnoky P., Banfalvi Z., Kondorosi A.;
RT "The cycHJKL genes of Rhizobium meliloti involved in cytochrome c
RT biogenesis are required for 'respiratory' nitrate reduction ex planta and
RT for nitrogen fixation during symbiosis.";
RL Mol. Gen. Genet. 247:39-47(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}; Periplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
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DR EMBL; X82560; CAA57907.1; -; Genomic_DNA.
DR EMBL; AL591688; CAC45592.1; -; Genomic_DNA.
DR PIR; S54751; S49617.
DR RefSeq; NP_385126.1; NC_003047.1.
DR RefSeq; WP_010968990.1; NC_003047.1.
DR AlphaFoldDB; P45406; -.
DR SMR; P45406; -.
DR STRING; 266834.SMc02364; -.
DR EnsemblBacteria; CAC45592; CAC45592; SMc02364.
DR GeneID; 61602485; -.
DR KEGG; sme:SMc02364; -.
DR PATRIC; fig|266834.11.peg.2424; -.
DR eggNOG; COG3088; Bacteria.
DR HOGENOM; CLU_107187_2_0_5; -.
DR OMA; MIAADMR; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.640; -; 1.
DR InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR Pfam; PF03918; CcmH; 1.
PE 3: Inferred from homology;
KW Cytochrome c-type biogenesis; Heme; Iron; Membrane; Metal-binding;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..151
FT /note="Cytochrome c-type biogenesis protein CcmH"
FT /id="PRO_0000006610"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 45
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
FT BINDING 48
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="G -> A (in Ref. 1; CAA57907)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="Missing (in Ref. 1; CAA57907)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="D -> A (in Ref. 1; CAA57907)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 151 AA; 16598 MW; 97BDB71EE956761C CRC64;
MIRLLIALFL LLASVAPGFA VNPDEVLADP ALEARARAIS AQLRCMVCQN QSIDDSNAEL
AKDLRLLVRE RLKNGDSDEA VISYVVSRYG EFVLLNPRLE AKTLVLWGMP AILLVAGIIT
LVVAARRRGA RVPGAPLSDE EKERLDRLLR P
