CCMH_SHIFL
ID CCMH_SHIFL Reviewed; 350 AA.
AC P0ABN0; P33925;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cytochrome c-type biogenesis protein CcmH;
DE Flags: Precursor;
GN Name=ccmH; OrderedLocusNames=SF2278, S2408;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: May be required for the biogenesis of c-type cytochromes.
CC Possible subunit of a heme lyase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
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DR EMBL; AE005674; AAN43797.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17614.1; -; Genomic_DNA.
DR RefSeq; NP_708090.1; NC_004337.2.
DR RefSeq; WP_001211575.1; NZ_WPGW01000022.1.
DR AlphaFoldDB; P0ABN0; -.
DR BMRB; P0ABN0; -.
DR SMR; P0ABN0; -.
DR STRING; 198214.SF2278; -.
DR EnsemblBacteria; AAN43797; AAN43797; SF2278.
DR EnsemblBacteria; AAP17614; AAP17614; S2408.
DR GeneID; 1025443; -.
DR GeneID; 58388765; -.
DR KEGG; sfl:SF2278; -.
DR KEGG; sfx:S2408; -.
DR PATRIC; fig|198214.7.peg.2729; -.
DR HOGENOM; CLU_036074_0_0_6; -.
DR OMA; KIWFVSG; -.
DR OrthoDB; 480718at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.640; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF03918; CcmH; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Heme;
KW Iron; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW TPR repeat; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..350
FT /note="Cytochrome c-type biogenesis protein CcmH"
FT /id="PRO_0000042812"
FT TOPO_DOM 19..96
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..350
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 222..255
FT /note="TPR 1"
FT REPEAT 293..326
FT /note="TPR 2"
FT BINDING 43
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
FT BINDING 46
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
SQ SEQUENCE 350 AA; 39089 MW; 002126A1F17F493F CRC64;
MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS IADSNSMIAT
DLRQKVYELM QEGKSKKEIV DYMVARYGNF VTYDPPLTPL TVLLWVLPVV AIGIGGWVIY
ARSRRRVRVV PEAFPEQSVP EGKRAGYVVY LPGIVVALIV AGVSYYQTGN YQQVKIWQQA
TAQAPALLDR ALDPKADPLN EEEMSRLALG MRTQLQKNPG DIEGWIMLGR VGMALGNASI
ATDAYATAYR LDPKNSDAAL GYAEALTRSS DPNDNRLGGE LLRQLVRTDH SNIRVLSMYA
FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
