CCN3_COTJA
ID CCN3_COTJA Reviewed; 353 AA.
AC P42642;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=CCN family member 3;
DE AltName: Full=Cellular communication network factor 3 {ECO:0000250|UniProtKB:P48745};
DE AltName: Full=Nephroblastoma-overexpressed gene protein;
DE AltName: Full=Protein NOV;
DE Flags: Precursor;
GN Name=CCN3; Synonyms=NOV;
OS Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Perdicinae; Coturnix.
OX NCBI_TaxID=93934;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Weiskirchen R., Bister K.;
RL Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Immediate-early protein likely to play a role in cell growth
CC regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QZQ5}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q9QZQ5}. Cell junction, gap junction
CC {ECO:0000250|UniProtKB:Q9QZQ5}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
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DR EMBL; U13063; AAA21128.1; -; mRNA.
DR RefSeq; NP_001310148.1; NM_001323219.1.
DR AlphaFoldDB; P42642; -.
DR SMR; P42642; -.
DR Ensembl; ENSCJPT00005009151; ENSCJPP00005005682; ENSCJPG00005005391.
DR GeneID; 107310512; -.
DR KEGG; cjo:107310512; -.
DR CTD; 4856; -.
DR GeneTree; ENSGT00940000159963; -.
DR OrthoDB; 999958at2759; -.
DR Proteomes; UP000694412; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:1990523; P:bone regeneration; IEA:Ensembl.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0035767; P:endothelial cell chemotaxis; IEA:Ensembl.
DR GO; GO:0071603; P:endothelial cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0010761; P:fibroblast migration; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:1902731; P:negative regulation of chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0090027; P:negative regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0014909; P:smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0048659; P:smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl.
DR Gene3D; 2.20.100.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR SUPFAM; SSF82895; SSF82895; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cytoplasm; Disulfide bond; Gap junction; Glycoprotein;
KW Growth factor; Proto-oncogene; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..353
FT /note="CCN family member 3"
FT /id="PRO_0000014414"
FT DOMAIN 29..103
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT DOMAIN 106..172
FT /note="VWFC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 203..248
FT /note="TSP type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 260..334
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 260..297
FT /evidence="ECO:0000250"
FT DISULFID 277..311
FT /evidence="ECO:0000250"
FT DISULFID 288..327
FT /evidence="ECO:0000250"
FT DISULFID 291..329
FT /evidence="ECO:0000250"
FT DISULFID 296..333
FT /evidence="ECO:0000250"
SQ SEQUENCE 353 AA; 38667 MW; 717D9F8533882E89 CRC64;
MEPGGGHSLP VLLLLLLLLL LRPSEVNGRE APCPRPCGGR CPAEPPRCAP GVPAVLDGCG
CCLVCARQRG ESCSPLLPCD ESGGLYCDRG PEDGGGTGIC MVLEGDNCVF DGMIYRNGET
FQPSCKYQCT CRDGQIGCLP RCNLGLLLPG PDCPFPRKIE VPGECCEKWV CEPRDEVLLG
GFAMAAYRQE ATLGIDVSDS SANCIEQTTE WSACSRSCGM GFSTRVTNRN QQCEMVKQTR
LCMMRPCENE EPSDKKGKKC IRTKKSMKAV RFEYKNCTSV QTYKPRYCGL CNDGRCCTPH
NTKTIQVEFR CPQGKFLKKP MMLINTCVCH GNCPQSNNAF FQPLDPMSSE AKI
