CCN6_MOUSE
ID CCN6_MOUSE Reviewed; 354 AA.
AC D3Z5L9;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Cellular communication network factor 6;
DE AltName: Full=CCN family member 6;
DE AltName: Full=WNT1-inducible-signaling pathway protein 3 {ECO:0000303|PubMed:15601861};
DE Short=WISP-3 {ECO:0000303|PubMed:15601861};
DE Flags: Precursor;
GN Name=Ccn6 {ECO:0000312|MGI:MGI:2685581};
GN Synonyms=Wisp3 {ECO:0000303|PubMed:15601861};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=15601861; DOI=10.1128/mcb.25.1.414-421.2005;
RA Kutz W.E., Gong Y., Warman M.L.;
RT "WISP3, the gene responsible for the human skeletal disease progressive
RT pseudorheumatoid dysplasia, is not essential for skeletal function in
RT mice.";
RL Mol. Cell. Biol. 25:414-421(2005).
CC -!- FUNCTION: Plays a role in mitochondrial electron transport and
CC mitochondrial respiration. {ECO:0000250|UniProtKB:O95389}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O95389}.
CC Mitochondrion {ECO:0000250|UniProtKB:O95389}. Note=Associated with
CC membranes. {ECO:0000250|UniProtKB:O95389}.
CC -!- DISRUPTION PHENOTYPE: Deficient mice are viable and fertile with no
CC obvious abnormalities in size, weight, skeletal development,
CC ossification, or the occurrence of joint disease.
CC {ECO:0000269|PubMed:15601861}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
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DR EMBL; AC153958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48537.1; -.
DR RefSeq; NP_001120848.1; NM_001127376.1.
DR AlphaFoldDB; D3Z5L9; -.
DR SMR; D3Z5L9; -.
DR STRING; 10090.ENSMUSP00000076003; -.
DR GlyGen; D3Z5L9; 1 site.
DR iPTMnet; D3Z5L9; -.
DR PhosphoSitePlus; D3Z5L9; -.
DR PaxDb; D3Z5L9; -.
DR PeptideAtlas; D3Z5L9; -.
DR PRIDE; D3Z5L9; -.
DR ProteomicsDB; 297851; -.
DR Antibodypedia; 32438; 192 antibodies from 25 providers.
DR DNASU; 327743; -.
DR Ensembl; ENSMUST00000076713; ENSMUSP00000076003; ENSMUSG00000062074.
DR GeneID; 327743; -.
DR KEGG; mmu:327743; -.
DR UCSC; uc011xcu.1; mouse.
DR CTD; 8838; -.
DR MGI; MGI:2685581; Ccn6.
DR VEuPathDB; HostDB:ENSMUSG00000062074; -.
DR eggNOG; ENOG502QW30; Eukaryota.
DR GeneTree; ENSGT00940000160119; -.
DR HOGENOM; CLU_063247_2_0_1; -.
DR InParanoid; D3Z5L9; -.
DR OMA; LVQTTPW; -.
DR OrthoDB; 601212at2759; -.
DR PhylomeDB; D3Z5L9; -.
DR TreeFam; TF326070; -.
DR BioGRID-ORCS; 327743; 4 hits in 74 CRISPR screens.
DR PRO; PR:D3Z5L9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; D3Z5L9; protein.
DR Bgee; ENSMUSG00000062074; Expressed in secondary oocyte and 39 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI.
DR GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.20.100.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR SUPFAM; SSF82895; SSF82895; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Growth factor; Mitochondrion;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..354
FT /note="Cellular communication network factor 6"
FT /evidence="ECO:0000250"
FT /id="PRO_0000415855"
FT DOMAIN 40..117
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT DOMAIN 208..253
FT /note="TSP type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 268..342
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT CARBOHYD 308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 209..238
FT /evidence="ECO:0000250"
FT DISULFID 219..223
FT /evidence="ECO:0000250"
FT DISULFID 247..252
FT /evidence="ECO:0000250"
FT DISULFID 268..305
FT /evidence="ECO:0000250"
FT DISULFID 285..319
FT /evidence="ECO:0000250"
FT DISULFID 296..335
FT /evidence="ECO:0000250"
FT DISULFID 299..337
FT /evidence="ECO:0000250"
SQ SEQUENCE 354 AA; 39379 MW; F45C5CD8896D1647 CRC64;
MRRLLFCTLL MTGLTQLCCR TQGSAPQDST PGGRPGAALE VYQRTEVCRW PCRCPPQRPT
CPPGVSLVRD GCGCCKVCAK QPGDTCNEAE ICDPHKGLYC DYSGDTPRYE TGVCAYLVAV
GCEFNRVYYQ NGQVFQPHPL FSCLCVSGAI GCTPLFIPKL AGSNCSAAKG RRKTDPPNCG
RGTLQQQNSA SYKTMSAYRN LPLTWRKKCL VQATKWTPCS RTCGMGISNR VTNDNANCEM
RKERRLCYIQ PCSRNTSQAV KIPRGETCQP TFQLPKAEKF VFSGCSSTQS YRPTFCGICL
DKRCCVPNKS KMITVRFDCP SEGSFKWQML WVTSCVCQRD CREPGDIFSE LRIL
