CCNA1_CAEEL
ID CCNA1_CAEEL Reviewed; 485 AA.
AC P34638;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=G2/mitotic-specific cyclin-A1;
GN Name=cya-1; ORFNames=ZK507.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RX PubMed=7545687; DOI=10.1242/jcs.108.6.2415;
RA Kreutzer M.A., Richards J.P., de Silva-Udawatta M.N., Temenak J.J.,
RA Knoblich J.A., Lehner C.F., Bennett K.L.;
RT "Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene
RT family, an ancestral cyclin B3 and differential germline expression.";
RL J. Cell Sci. 108:2415-2424(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=24204299; DOI=10.1371/journal.pgen.1003884;
RA Yan B., Memar N., Gallinger J., Conradt B.;
RT "Coordination of cell proliferation and cell fate determination by CES-1
RT snail.";
RL PLoS Genet. 9:E1003884-E1003884(2013).
CC -!- FUNCTION: Involved in the control of the cell cycle after S phase. May
CC bind to and activate cdk-1 and/or cdk-2 to promote cell cycle
CC progression. Necessary for embryogenesis.
CC {ECO:0000269|PubMed:24204299}.
CC -!- INTERACTION:
CC P34638; P34647: mcm-6; NbExp=4; IntAct=EBI-2421605, EBI-2006759;
CC -!- TISSUE SPECIFICITY: Expressed in the cell lineages ABarp, C and E as
CC well as the NSM neuroblasts. {ECO:0000269|PubMed:24204299}.
CC -!- DISRUPTION PHENOTYPE: Homozygous mutants are not viable. Partial loss-
CC of-function mutation bc416 causes cell division defects with a
CC reduction in the number of dividing NSM neuroblasts and some embryonic
CC lethality. {ECO:0000269|PubMed:24204299}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; U20902; AAA84393.1; -; mRNA.
DR EMBL; Z29116; CAA82372.1; -; Genomic_DNA.
DR PIR; D88548; D88548.
DR PIR; S40740; S40740.
DR RefSeq; NP_499018.1; NM_066617.6.
DR AlphaFoldDB; P34638; -.
DR SMR; P34638; -.
DR BioGRID; 41486; 6.
DR IntAct; P34638; 1.
DR STRING; 6239.ZK507.6; -.
DR EPD; P34638; -.
DR PaxDb; P34638; -.
DR PeptideAtlas; P34638; -.
DR PRIDE; P34638; -.
DR EnsemblMetazoa; ZK507.6.1; ZK507.6.1; WBGene00000863.
DR GeneID; 176287; -.
DR KEGG; cel:CELE_ZK507.6; -.
DR UCSC; ZK507.6; c. elegans.
DR CTD; 176287; -.
DR WormBase; ZK507.6; CE03820; WBGene00000863; cya-1.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00940000165715; -.
DR HOGENOM; CLU_020695_2_4_1; -.
DR InParanoid; P34638; -.
DR OMA; CCFANLQ; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; P34638; -.
DR Reactome; R-CEL-1538133; G0 and Early G1.
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR Reactome; R-CEL-5693607; Processing of DNA double-strand break ends.
DR Reactome; R-CEL-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
DR Reactome; R-CEL-68949; Orc1 removal from chromatin.
DR Reactome; R-CEL-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-CEL-69273; Cyclin A/B1/B2 associated events during G2/M transition.
DR Reactome; R-CEL-69563; p53-Dependent G1 DNA Damage Response.
DR Reactome; R-CEL-69656; Cyclin A:Cdk2-associated events at S phase entry.
DR Reactome; R-CEL-8951664; Neddylation.
DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:P34638; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000863; Expressed in embryo and 4 other tissues.
DR GO; GO:0097124; C:cyclin A2-CDK2 complex; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:UniProtKB.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Mitosis; Reference proteome.
FT CHAIN 1..485
FT /note="G2/mitotic-specific cyclin-A1"
FT /id="PRO_0000080343"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 55510 MW; D5388642187B7E92 CRC64;
MRSALSLKPS NGNAAKSQAV NNKNVIKNAP LGGKLTRQIG TSNLLQQALP SKKIDESPII
KIDAKDSFKV FEDQEPEKEN SSENVDATEK DSNVIPAEDN NMIHELERKM EEKSRAEKLK
FKFMQTRDNS DITSRFSEPP SEFSVLCDDD DCDKVSVASS TFTTSVRATF SSFHFDENQR
KKEFGKEEAV KKIQKKAAKE ARDDSMFSSE EFFPDIIKYM LHRQTKNRAS HECFDIQSQV
NEEMRTILID WFSDVVKEYN FQKETFHLAV SLVDRALSMF NIDKMRFQLV GTTSMMIAVK
YEEIFPPEIE DFALITDNTY RVPDILLMER FLLGKFDFVV AMPTSSWFGT CFAKRMNFTK
KMRNTVHYLL ELSLIDVHFL RYRPSDIAAA ACCFANLQAD VESWPQKMVD DTGISTEDFV
DVLRDLHRMY LNASTADFKS IFYNYSETAQ MEVALLPAPT DKLRSMFPSI FVTAPKSSND
SSSPQ
