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CCNA1_MOUSE
ID   CCNA1_MOUSE             Reviewed;         421 AA.
AC   Q61456; Q8C5U1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Cyclin-A1;
GN   Name=Ccna1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Testis;
RX   PubMed=8565853; DOI=10.1242/dev.122.1.53;
RA   Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F.,
RA   Wolgemuth D.J., Carrington M.;
RT   "A distinct cyclin A is expressed in germ cells in the mouse.";
RL   Development 122:53-64(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=9843212; DOI=10.1038/3855;
RA   Liu D., Matzuk M.M., Sung W.K., Guo Q., Wang P., Wolgemuth D.J.;
RT   "Cyclin A1 is required for meiosis in the male mouse.";
RL   Nat. Genet. 20:377-380(1998).
RN   [5]
RP   FUNCTION.
RC   STRAIN=Swiss Webster;
RX   PubMed=10068472; DOI=10.1006/dbio.1998.9156;
RA   Ravnik S.E., Wolgemuth D.J.;
RT   "Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins
RT   and their associated cyclin-dependent kinases are differentially expressed
RT   in the germ-cell lineage.";
RL   Dev. Biol. 207:408-418(1999).
RN   [6]
RP   IDENTIFICATION IN A COMPLEX WITH CDK2; CABLES1 AND CCNE1.
RX   PubMed=11585773;
RA   Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.;
RT   "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell
RT   growth, and is lost in many human colon and squamous cancers.";
RL   Cancer Res. 61:7325-7332(2001).
CC   -!- FUNCTION: May be involved in the control of the cell cycle at the G1/S
CC       (start) and G2/M (mitosis) transitions. May primarily function in the
CC       control of the germline meiotic cell cycle and additionally in the
CC       control of mitotic cell cycle in some somatic cells.
CC       {ECO:0000269|PubMed:10068472, ECO:0000269|PubMed:9843212}.
CC   -!- SUBUNIT: Interacts with INCA1 and KLHDC9 (By similarity). Interacts
CC       with the CDK2 and CDC2 protein kinases to form a serine/threonine
CC       kinase holoenzyme complex. The cyclin subunit imparts substrate
CC       specificity to the complex. Found in a complex with CDK2, CABLES1 and
CC       CCNE1. {ECO:0000250|UniProtKB:P78396, ECO:0000269|PubMed:11585773}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle. Note=In oocytes at least, it associates with the spindle
CC       during metaphase.
CC   -!- TISSUE SPECIFICITY: Testis and ovaries.
CC   -!- DEVELOPMENTAL STAGE: In male germ cells just prior to or during the
CC       first, but not the second meiotic division.
CC   -!- PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-
CC       promoting complex (APC/C), leading to its degradation by the
CC       proteasome. Deubiquitinated and stabilized by USP37 enables entry into
CC       S phase (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: CCNA1 -/- males are sterile due to a block of
CC       spermatogenesis before the first meiotic division, whereas females are
CC       normal.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X84311; CAA59053.1; -; mRNA.
DR   EMBL; AK077114; BAC36619.1; -; mRNA.
DR   EMBL; BC120518; AAI20519.1; -; mRNA.
DR   EMBL; BC125436; AAI25437.1; -; mRNA.
DR   CCDS; CCDS17356.1; -.
DR   RefSeq; NP_001292150.1; NM_001305221.1.
DR   RefSeq; NP_031654.2; NM_007628.3.
DR   RefSeq; XP_006501012.1; XM_006500949.2.
DR   RefSeq; XP_006501013.1; XM_006500950.3.
DR   RefSeq; XP_006501014.1; XM_006500951.2.
DR   RefSeq; XP_006501015.1; XM_006500952.2.
DR   RefSeq; XP_011238305.1; XM_011240003.2.
DR   AlphaFoldDB; Q61456; -.
DR   SMR; Q61456; -.
DR   BioGRID; 198544; 6.
DR   ComplexPortal; CPX-2061; Cyclin A1-CDK1 complex.
DR   ComplexPortal; CPX-2065; Cyclin A1-CDK2 complex.
DR   CORUM; Q61456; -.
DR   STRING; 10090.ENSMUSP00000029368; -.
DR   iPTMnet; Q61456; -.
DR   PhosphoSitePlus; Q61456; -.
DR   PaxDb; Q61456; -.
DR   PRIDE; Q61456; -.
DR   ProteomicsDB; 281335; -.
DR   Antibodypedia; 4520; 542 antibodies from 37 providers.
DR   DNASU; 12427; -.
DR   Ensembl; ENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793.
DR   Ensembl; ENSMUST00000197238; ENSMUSP00000142692; ENSMUSG00000027793.
DR   Ensembl; ENSMUST00000198320; ENSMUSP00000143447; ENSMUSG00000027793.
DR   GeneID; 12427; -.
DR   KEGG; mmu:12427; -.
DR   UCSC; uc008pfy.3; mouse.
DR   CTD; 8900; -.
DR   MGI; MGI:108042; Ccna1.
DR   VEuPathDB; HostDB:ENSMUSG00000027793; -.
DR   eggNOG; KOG0654; Eukaryota.
DR   GeneTree; ENSGT00940000157940; -.
DR   HOGENOM; CLU_020695_3_2_1; -.
DR   InParanoid; Q61456; -.
DR   OMA; YKSSKYC; -.
DR   OrthoDB; 993640at2759; -.
DR   PhylomeDB; Q61456; -.
DR   TreeFam; TF101002; -.
DR   Reactome; R-MMU-1538133; G0 and Early G1.
DR   Reactome; R-MMU-171319; Telomere Extension By Telomerase.
DR   Reactome; R-MMU-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-MMU-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR   Reactome; R-MMU-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-MMU-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-MMU-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR   Reactome; R-MMU-5689880; Ub-specific processing proteases.
DR   Reactome; R-MMU-5693607; Processing of DNA double-strand break ends.
DR   Reactome; R-MMU-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
DR   Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-MMU-6804757; Regulation of TP53 Degradation.
DR   Reactome; R-MMU-68911; G2 Phase.
DR   Reactome; R-MMU-68949; Orc1 removal from chromatin.
DR   Reactome; R-MMU-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-MMU-69273; Cyclin A/B1/B2 associated events during G2/M transition.
DR   Reactome; R-MMU-69563; p53-Dependent G1 DNA Damage Response.
DR   Reactome; R-MMU-69656; Cyclin A:Cdk2-associated events at S phase entry.
DR   BioGRID-ORCS; 12427; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q61456; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q61456; protein.
DR   Bgee; ENSMUSG00000027793; Expressed in spermatid and 36 other tissues.
DR   ExpressionAtlas; Q61456; baseline and differential.
DR   Genevisible; Q61456; MM.
DR   GO; GO:0097123; C:cyclin A1-CDK2 complex; IDA:MGI.
DR   GO; GO:0097124; C:cyclin A2-CDK2 complex; IBA:GO_Central.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR032447; Cyclin-A_N.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   Pfam; PF16500; Cyclin_N2; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cyclin; Cytoplasm; Cytoskeleton;
KW   Developmental protein; Differentiation; Meiosis; Mitosis; Nucleus;
KW   Reference proteome; Spermatogenesis; Ubl conjugation.
FT   CHAIN           1..421
FT                   /note="Cyclin-A1"
FT                   /id="PRO_0000080334"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        176
FT                   /note="R -> P (in Ref. 1; CAA59053)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  47772 MW;  FF717D0065B954E9 CRC64;
     MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR RTCGQEITAI
     RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ GDRDTCSGKE GIIFEDVYEV
     DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ SEEATDFGSD VINVTEYAEE IHRYLREAEV
     RHRPKAHYMR KQPDITEGMR AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG
     KLQLVGTAAI LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT
     NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL ANYIVNRHFW
     PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK YKASKYLHVS LMEPPVVLPL
     Q
 
 
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