ID   CCNB1_ORYLA             Reviewed;         404 AA.
AC   Q9IBG1; Q9IBF9;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=G2/mitotic-specific cyclin-B1;
GN   Name=ccnb1;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RA   Mita K., Ohbayashi T., Tomita K., Shimizu Y., Kondo T., Yamashita M.;
RT   "Differential expression of cyclins B1 and B2 during medaka (Oryzias
RT   latipes) spermatogenesis.";
RL   Zool. Sci. 17:365-374(2000).
CC   -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC       (mitosis) transition. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the CDK1 protein kinase to form a
CC       serine/threonine kinase holoenzyme complex also known as maturation
CC       promoting factor (MPF). The cyclin subunit imparts substrate
CC       specificity to the complex (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9IBG1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9IBG1-2; Sequence=VSP_001250, VSP_001251;
CC   -!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly
CC       destroyed at mitosis.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB030069; BAA89697.1; -; mRNA.
DR   EMBL; AB030071; BAA89699.1; -; mRNA.
DR   RefSeq; NP_001098137.1; NM_001104667.1.
DR   AlphaFoldDB; Q9IBG1; -.
DR   SMR; Q9IBG1; -.
DR   STRING; 8090.ENSORLP00000017132; -.
DR   GeneID; 100049212; -.
DR   KEGG; ola:100049212; -.
DR   CTD; 891; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   InParanoid; Q9IBG1; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0097125; C:cyclin B1-CDK1 complex; IBA:GO_Central.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell cycle; Cell division; Cyclin; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..404
FT                   /note="G2/mitotic-specific cyclin-B1"
FT                   /id="PRO_0000080358"
FT   VAR_SEQ         289..306
FT                   /note="TAEQHTLAKYLLELSMVD -> WRGVGAANCSLPPLHVLR (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_001250"
FT   VAR_SEQ         307..404
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_001251"
FT   CONFLICT        158
FT                   /note="Q -> H (in Ref. 1; BAA89699)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   404 AA;  45080 MW;  31C0992BCB4B25AB CRC64;
     MALRVTRNRL ASTRAELGGK TCSVAGPTQK PRAALGEIGN VAVINKDVTK KTIKTEVAKK
     TKIPAKAEKI ELPKAAVVPV KPAPEVQVTE VPDQAEPASP TPMETSGCES ADLCQAFSDV
     ILNTAIRDVD ADDYDNPMLC SEYVKDIYKY LRQLEMEQSV KPNYLEGQEI TGNMRAILID
     WLVQVGLKFR LLQETMYMTV GIIDRFLQDH PVPKKQLQLV GVTAMFLASK YEEMYPPEIS
     DFAYVTDRAY TTAQIRDMEM TILRVLKFQL GRPLPLQFLR RASKIYEVTA EQHTLAKYLL
     ELSMVDYDMA HFSPSLVASA ALALTLKVLD AGEWDVTLQH YMEYTAETLT PVMAHIAKNV
     VKVNNGQTKH MAIKGKYSTS KQMRIATISQ LKSSVVKDLA TQIS