ID   CCNB2_CHICK             Reviewed;         399 AA.
AC   P29332;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=G2/mitotic-specific cyclin-B2;
GN   Name=CCNB2; Synonyms=CYCB2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1532584; DOI=10.1083/jcb.117.1.213;
RA   Gallant P., Nigg E.A.;
RT   "Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when
RT   expressed as a non-destructible mutant, causes mitotic arrest in HeLa
RT   cells.";
RL   J. Cell Biol. 117:213-224(1992).
CC   -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC       (mitosis) transition.
CC   -!- SUBUNIT: Interacts with the CDK1 protein kinase to form a
CC       serine/threonine kinase holoenzyme complex also known as maturation
CC       promoting factor (MPF). The cyclin subunit imparts substrate
CC       specificity to the complex.
CC   -!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly
CC       destroyed at mitosis.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X62531; CAA44392.1; -; mRNA.
DR   PIR; S23596; S23596.
DR   RefSeq; NP_001004369.1; NM_001004369.1.
DR   AlphaFoldDB; P29332; -.
DR   SMR; P29332; -.
DR   STRING; 9031.ENSGALP00000006605; -.
DR   PaxDb; P29332; -.
DR   Ensembl; ENSGALT00000006616; ENSGALP00000006605; ENSGALG00000004161.
DR   GeneID; 415400; -.
DR   KEGG; gga:415400; -.
DR   CTD; 891; -.
DR   VEuPathDB; HostDB:geneid_415400; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00940000155405; -.
DR   HOGENOM; CLU_020695_2_1_1; -.
DR   InParanoid; P29332; -.
DR   OMA; VFAIEWA; -.
DR   OrthoDB; 993640at2759; -.
DR   PhylomeDB; P29332; -.
DR   TreeFam; TF101001; -.
DR   Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-GGA-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-GGA-2980767; Activation of NIMA Kinases NEK9, NEK6, NEK7.
DR   Reactome; R-GGA-2995383; Initiation of Nuclear Envelope (NE) Reformation.
DR   Reactome; R-GGA-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-GGA-69273; Cyclin A/B1/B2 associated events during G2/M transition.
DR   PRO; PR:P29332; -.
DR   Proteomes; UP000000539; Chromosome 10.
DR   Bgee; ENSGALG00000004161; Expressed in spermatid and 14 other tissues.
DR   ExpressionAtlas; P29332; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:AgBase.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008315; P:G2/MI transition of meiotic cell cycle; IEA:Ensembl.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR   GO; GO:0007057; P:spindle assembly involved in female meiosis I; IEA:Ensembl.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR   GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Mitosis; Reference proteome.
FT   CHAIN           1..399
FT                   /note="G2/mitotic-specific cyclin-B2"
FT                   /id="PRO_0000080364"
FT   REGION          58..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  44652 MW;  D5FA0BC63D50A18F CRC64;
     MALTRRAAVM RGVENAVTGH NTKAKVQVTG KRAVLEEIGN KVARGSNVPK KTDCIKPPVK
     ATKGPGKMTN TVVPPKPPAA VNQAVKDTTT ASKVLSPVPM DVSMQEEDLC QAFSDVLLHN
     IEDIDADDSG NPQLCSDYVK DIYLYLRQLE LQQSVRPHYL DGKTINGRMR AILVDWLVQV
     HSRFQLLQET LYMCVAVMDR FLQSHPVPRK RLQLVGVTAL LLASKYEEMY SPDIADFVYI
     TDNAYNSAEV REMEITILKE LNFDLGRPLP LHFLRRASKA GEADAEQHTL AKYLMELTLI
     DYDMVHYHPS EIAAAALCLS QKVLGHDKWG TKQQYYTGYA EDSLAMTMKH MAKNVVKVNE
     NLTKYTAVRN KYASSKLLRI STISQLNSKT IKDLAASLL