ID   CCNB2_ORYLA             Reviewed;         387 AA.
AC   Q9IBG0; Q9IBF8;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=G2/mitotic-specific cyclin-B2;
GN   Name=ccnb2;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RA   Mita K., Ohbayashi T., Tomita K., Shimizu Y., Kondo T., Yamashita M.;
RT   "Differential expression of cyclins B1 and B2 during medaka (Oryzias
RT   latipes) spermatogenesis.";
RL   Zool. Sci. 17:365-374(2000).
CC   -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC       (mitosis) transition. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the CDK1 protein kinase to form a
CC       serine/threonine kinase holoenzyme complex also known as maturation
CC       promoting factor (MPF). The cyclin subunit imparts substrate
CC       specificity to the complex (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9IBG0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9IBG0-2; Sequence=VSP_001252;
CC   -!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly
CC       destroyed at mitosis.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB030070; BAA89698.1; -; mRNA.
DR   EMBL; AB030072; BAA89700.1; -; mRNA.
DR   RefSeq; NP_001098138.1; NM_001104668.1.
DR   AlphaFoldDB; Q9IBG0; -.
DR   SMR; Q9IBG0; -.
DR   STRING; 8090.ENSORLP00000000759; -.
DR   GeneID; 100049213; -.
DR   KEGG; ola:100049213; -.
DR   CTD; 9133; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   InParanoid; Q9IBG0; -.
DR   OrthoDB; 993640at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell cycle; Cell division; Cyclin; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..387
FT                   /note="G2/mitotic-specific cyclin-B2"
FT                   /id="PRO_0000080368"
FT   VAR_SEQ         48..75
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_001252"
FT   CONFLICT        387
FT                   /note="H -> P (in Ref. 1; BAA89700)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   387 AA;  43326 MW;  E63450DD3EF37EDA CRC64;
     MSSVEIVAQQ LLAAEHPRRM GKGAAADPRR AALGELTNLN AAAATNGKVG PAKKPLKASC
     AQKPKLTQLV ASMIQTGAAA SAPVLAKPSV KEEQELCQAF SEVLLAVQDV DEQDADQPQL
     CSQYVKDIYK YLHILEEQQP VRANYMQGYE VTERMRALLV DWLVQVHSRF QLLQETLYLT
     VAILDRFLQV HPVSRRKLQL VGVTAMLVAC KYEEMYAPEV GDFAYITDNA FTKSQIVEME
     QVILRSLSFQ LGRPLPLHFL RRATKVAGAD VEKHTLAKYL MELTLLDYHM VHYRPSEVAA
     AALCLSQLLL DGLPWSLTQQ QYSTYEEQHL KPIMQHMAKN VVLVNEGRTK FLAVKKKYSS
     SKLMKISLIP QLNSSTVKTM ADALHDH