CCNB_DICDI
ID CCNB_DICDI Reviewed; 436 AA.
AC P42524; Q552U0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=G2/mitotic-specific cyclin-B;
GN Name=cycB; Synonyms=clb1; ORFNames=DDB_G0275493;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2, and AX3;
RX PubMed=7699009; DOI=10.1242/jcs.107.11.3105;
RA Luo Q., Michaelis C., Weeks G.;
RT "Overexpression of a truncated cyclin B gene arrests Dictyostelium cell
RT division during mitosis.";
RL J. Cell Sci. 107:3105-3114(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP PROTEIN SEQUENCE OF 94-126; 341-351 AND 425-436, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Ura S., Insall R.H.;
RL Submitted (JUL-2009) to UniProtKB.
CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC (mitosis) transition.
CC -!- SUBUNIT: Interacts with the cdk1 protein kinase to form a
CC serine/threonine kinase holoenzyme complex also known as maturation
CC promoting factor (MPF). The cyclin subunit imparts substrate
CC specificity to the complex.
CC -!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly
CC destroyed at mitosis. Very low levels are seen in stationary-phase
CC cells (0 hour) which then increase to a maximum between 5 and 6 hours
CC (at which time cells begin to divide). Protein levels then decrease
CC until the end of cell division.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; U11056; AAC46498.1; -; Genomic_DNA.
DR EMBL; AAFI02000013; EAL69497.1; -; Genomic_DNA.
DR RefSeq; XP_643591.1; XM_638499.1.
DR AlphaFoldDB; P42524; -.
DR SMR; P42524; -.
DR STRING; 44689.DDB0185035; -.
DR PaxDb; P42524; -.
DR EnsemblProtists; EAL69497; EAL69497; DDB_G0275493.
DR GeneID; 8620178; -.
DR KEGG; ddi:DDB_G0275493; -.
DR dictyBase; DDB_G0275493; cycB.
DR eggNOG; KOG0653; Eukaryota.
DR HOGENOM; CLU_020695_12_4_1; -.
DR InParanoid; P42524; -.
DR OMA; MAVHVRF; -.
DR PhylomeDB; P42524; -.
DR Reactome; R-DDI-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR PRO; PR:P42524; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:dictyBase.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0051592; P:response to calcium ion; IDA:dictyBase.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Direct protein sequencing; Mitosis;
KW Reference proteome.
FT CHAIN 1..436
FT /note="G2/mitotic-specific cyclin-B"
FT /id="PRO_0000080384"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 49534 MW; 88D69C538218E401 CRC64;
MSTINNPLNI KTRSHSSMGG GMIMDENKVP KSSIGMDKKI GGTTGLKSHR GALSDLTNNT
HQTTGMATKT VQLSNNNIIM PQPTNTRNNI ITRSKSIIDN GASLRNSALI SGVLPNANGP
VNKVQKRDIQ SMEMMNNIPQ QPVMIDDVDN DTNMIQEEQM VIDITEVPEN IDIYDSHDPQ
CVGEYVNEIF AYYREKEQID KIDKDYIKNQ YHINERMRAI LVDWMMAVHV RFKLLSETFF
LSVNIVDRYL AKVMIPVTKL QLVGITAILL ACKYEEIYSP QIKDFVHTSD DACTHAEVID
MERQILSTLQ FHMSVATPLH FLRRFSKAAG SDSRTHSLSK YLSELSMVEY RMVQFVPSMI
AAASIYVARR MTMKSGPYWN VTLEYYTCYK ESEILQCAQE LKEVRKRADT SNLKATRKKY
LSSKLMEVAA IPVVEF
