ID   CCNC_CAEBR              Reviewed;         298 AA.
AC   P0C654; A8XMG9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Cyclin-C;
GN   Name=cic-1; ORFNames=CBG15657;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; HE600979; CAP33845.2; -; Genomic_DNA.
DR   AlphaFoldDB; P0C654; -.
DR   SMR; P0C654; -.
DR   STRING; 6238.CBG15657; -.
DR   EnsemblMetazoa; CBG15657a.1; CBG15657a.1; WBGene00035815.
DR   WormBase; CBG15657a; CBP35555; WBGene00035815; Cbr-cic-1.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_1_1_1; -.
DR   InParanoid; P0C654; -.
DR   OMA; SHHQQWL; -.
DR   OrthoDB; 1079428at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Developmental protein; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..298
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000314263"
FT   DOMAIN          46..162
FT                   /note="Cyclin N-terminal"
FT   REGION          278..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  34463 MW;  B34686B1BAD561D6 CRC64;
     MALDFWKSSH AQQWIFDKTE IWKQRAEDMK TYSEEEYSRL NIFWANFITA VATECAHSQA
     NVGCKLRQQV IATAIVYFKR FYLRQSFRDM CPFLVASTAL FLACKVEEHT TLSVSSFLKN
     TALVLPKRWG VAFETNSAKN GVLYDSEFIL VEILDCCLVV HHATRPMFEL LEDWKQHTLT
     STNTPVKDFD QIEIQCQKVV NDTLRCDVGL MFAPHCIGLA SISVGMELMG RGEELEDWLV
     EVDTDMDKLA DCINQIYTMY QLWRSFDEKE EVKKLMAKLP KPNTPIPPPQ QQQSSYHM