ID   CCNC_CAEEL              Reviewed;         302 AA.
AC   Q9TYP2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Cyclin-C;
GN   Name=cic-1; ORFNames=H14E04.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; FO081521; CCD72187.1; -; Genomic_DNA.
DR   PIR; T33884; T33884.
DR   RefSeq; NP_497548.2; NM_065147.4.
DR   AlphaFoldDB; Q9TYP2; -.
DR   SMR; Q9TYP2; -.
DR   STRING; 6239.H14E04.5; -.
DR   EPD; Q9TYP2; -.
DR   PaxDb; Q9TYP2; -.
DR   PeptideAtlas; Q9TYP2; -.
DR   EnsemblMetazoa; H14E04.5.1; H14E04.5.1; WBGene00000506.
DR   GeneID; 175357; -.
DR   KEGG; cel:CELE_H14E04.5; -.
DR   UCSC; H14E04.5; c. elegans.
DR   CTD; 175357; -.
DR   WormBase; H14E04.5; CE34571; WBGene00000506; cic-1.
DR   eggNOG; KOG0794; Eukaryota.
DR   GeneTree; ENSGT00940000167379; -.
DR   HOGENOM; CLU_034754_1_1_1; -.
DR   InParanoid; Q9TYP2; -.
DR   OMA; SHHQQWL; -.
DR   OrthoDB; 1079428at2759; -.
DR   PhylomeDB; Q9TYP2; -.
DR   Reactome; R-CEL-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR   PRO; PR:Q9TYP2; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000506; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Developmental protein; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000314264"
FT   DOMAIN          46..152
FT                   /note="Cyclin N-terminal"
FT   REGION          281..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  35013 MW;  64BF6CE075D686C5 CRC64;
     MALNFWKSSH CQQWIFDKTE IWKQRAEDMK IYNEEEYNRL NIFWANFITA VATEGAHSQA
     NVGCKLRQQV IATAIIYFKR FYLRQSFRDM CPFLVASTAL FLACKVEEHT TLSVSSFLKN
     TAIVLPKRWG VTFETTSTKN GVVYDSEFIL VEILDCCLVV HHASRPMFEL LEDLKQFTQQ
     STIANQPIKD LEAIEAQCQK VANDSLRCDV SLIFPPHVIG LSSIMVAMEL MGRGEELEAW
     LVEVDTDFEK VTDCVEQIYK MYTLWKSFDE KEEVKKLMAK LPKPNQQPPP QQQHQHQQGY
     HL