ID   CCNC_CHICK              Reviewed;         283 AA.
AC   P55168;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Cyclin-C;
GN   Name=CCNC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8761291;
RA   Li H., Lahti J.M., Kidd V.J.;
RT   "Alternatively spliced cyclin C mRNA is widely expressed, cell cycle
RT   regulated, and encodes a truncated cyclin box.";
RL   Oncogene 13:705-712(1996).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. The cylin/CDK pair formed
CC       by CCNC/CDK8 also associates with the large subunit of RNA polymerase
CC       II (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U40873; AAB18947.1; -; Genomic_DNA.
DR   RefSeq; NP_001161237.1; NM_001167765.1.
DR   AlphaFoldDB; P55168; -.
DR   SMR; P55168; -.
DR   STRING; 9031.ENSGALP00000036437; -.
DR   PaxDb; P55168; -.
DR   Ensembl; ENSGALT00000037233; ENSGALP00000036437; ENSGALG00000015471.
DR   GeneID; 421791; -.
DR   KEGG; gga:421791; -.
DR   CTD; 892; -.
DR   VEuPathDB; HostDB:geneid_421791; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   GeneTree; ENSGT00940000155625; -.
DR   HOGENOM; CLU_034754_1_1_1; -.
DR   InParanoid; P55168; -.
DR   OMA; SHHQQWL; -.
DR   OrthoDB; 1079428at2759; -.
DR   PhylomeDB; P55168; -.
DR   Reactome; R-GGA-212436; Generic Transcription Pathway.
DR   PRO; PR:P55168; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000015471; Expressed in spermatocyte and 13 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000080423"
FT   DOMAIN          46..144
FT                   /note="Cyclin N-terminal"
FT   REGION          252..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  33259 MW;  6278DA16AE6A5660 CRC64;
     MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
     VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF
     SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV
     NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
     WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS