CCNC_DROME
ID CCNC_DROME Reviewed; 267 AA.
AC P25008; Q9VFF1;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Cyclin-C;
GN Name=CycC; Synonyms=CLND; ORFNames=CG7281;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=1836192; DOI=10.1101/gad.5.12a.2166;
RA Lahue E.E., Smith A.V., Orr-Weaver T.L.;
RT "A novel cyclin gene from Drosophila complements CLN function in yeast.";
RL Genes Dev. 5:2166-2175(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=1833067; DOI=10.1016/0092-8674(91)90043-x;
RA Leopold P., O'Farrell P.H.;
RT "An evolutionarily conserved cyclin homolog from Drosophila rescues yeast
RT deficient in G1 cyclins.";
RL Cell 66:1207-1216(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, INTERACTION, AND SUBCELLULAR LOCATION.
RX PubMed=8730095; DOI=10.1091/mbc.7.4.505;
RA Leclerc V., Tassan J.-P., O'Farrell P.H., Nigg E.A., Leopold P.;
RT "Drosophila Cdk8, a kinase partner of cyclin C that interacts with the
RT large subunit of RNA polymerase II.";
RL Mol. Biol. Cell 7:505-513(1996).
RN [7]
RP FUNCTION, AND INTERACTION WITH CYCC; KTO AND SKD.
RX PubMed=17290221; DOI=10.1038/sj.emboj.7601566;
RA Loncle N., Boube M., Joulia L., Boschiero C., Werner M., Cribbs D.L.,
RA Bourbon H.-M.;
RT "Distinct roles for Mediator Cdk8 module subunits in Drosophila
RT development.";
RL EMBO J. 26:1045-1054(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated gene transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. Binds to and activates cyclin-
CC dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain)
CC of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC the formation of a transcription initiation complex. Required for leg
CC and eye development and macrochaete specification or differentiation.
CC {ECO:0000269|PubMed:17290221, ECO:0000269|PubMed:1833067,
CC ECO:0000269|PubMed:1836192, ECO:0000269|PubMed:8730095}.
CC -!- SUBUNIT: Component of the Cdk8 module of the Mediator complex, composed
CC of CycC, Cdk8, kto and skd.
CC -!- INTERACTION:
CC P25008; P23572: Cdk1; NbExp=4; IntAct=EBI-195485, EBI-108689;
CC P25008; P48609: Cdk5; NbExp=4; IntAct=EBI-195485, EBI-94216;
CC P25008; Q9VT57: Cdk8; NbExp=2; IntAct=EBI-195485, EBI-163640;
CC P25008; Q9VW47: kto; NbExp=2; IntAct=EBI-195485, EBI-139710;
CC P25008; Q7KTX8: skd; NbExp=2; IntAct=EBI-195485, EBI-110730;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8730095}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically during
CC developmental periods of maximal cell division; most abundant in early
CC embryos and low levels in larvae, pupae and adults.
CC {ECO:0000269|PubMed:1836192}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; X62948; CAA44720.1; -; mRNA.
DR EMBL; M74906; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AE014297; AAF55109.1; -; Genomic_DNA.
DR EMBL; AY061425; AAL28973.1; -; mRNA.
DR PIR; A40269; A40269.
DR RefSeq; NP_476848.1; NM_057500.4.
DR AlphaFoldDB; P25008; -.
DR SMR; P25008; -.
DR BioGRID; 66871; 35.
DR DIP; DIP-17706N; -.
DR IntAct; P25008; 27.
DR MINT; P25008; -.
DR STRING; 7227.FBpp0082469; -.
DR PaxDb; P25008; -.
DR EnsemblMetazoa; FBtr0083010; FBpp0082469; FBgn0004597.
DR GeneID; 41801; -.
DR KEGG; dme:Dmel_CG7281; -.
DR CTD; 41801; -.
DR FlyBase; FBgn0004597; CycC.
DR VEuPathDB; VectorBase:FBgn0004597; -.
DR eggNOG; KOG0794; Eukaryota.
DR GeneTree; ENSGT00940000167379; -.
DR HOGENOM; CLU_034754_1_1_1; -.
DR InParanoid; P25008; -.
DR OMA; SHHQQWL; -.
DR OrthoDB; 1079428at2759; -.
DR PhylomeDB; P25008; -.
DR Reactome; R-DME-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR SignaLink; P25008; -.
DR BioGRID-ORCS; 41801; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41801; -.
DR PRO; PR:P25008; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004597; Expressed in thoracico-abdominal ganglion (Drosophila) and 23 other tissues.
DR Genevisible; P25008; DM.
DR GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:FlyBase.
DR GO; GO:0003712; F:transcription coregulator activity; IMP:UniProtKB.
DR GO; GO:0022416; P:chaeta development; IMP:FlyBase.
DR GO; GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.
DR GO; GO:0010508; P:positive regulation of autophagy; IGI:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0045498; P:sex comb development; IMP:FlyBase.
DR GO; GO:0034472; P:snRNA 3'-end processing; IDA:FlyBase.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR031658; Cyclin_C_2.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF16899; Cyclin_C_2; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Cyclin; Developmental protein; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..267
FT /note="Cyclin-C"
FT /id="PRO_0000080424"
FT DOMAIN 48..151
FT /note="Cyclin N-terminal"
SQ SEQUENCE 267 AA; 31292 MW; DA73CB7EA89149FE CRC64;
MAGNFWQSSH SQQWILDKPD LLRERQHDLL ALNEDEYQKV FIFFANVIQV LGEQLKLRQQ
VIATATVYFK RFYARNSLKN IDPLLLAPTC ILLASKVEEF GVISNSRLIS ICQSAIKTKF
SYAYAQEFPY RTNHILECEF YLLENLDCCL IVYQPYRPLL QLVQDMGQED QLLTLSWRIV
NDSLRTDVCL LYPPYQIAIA CLQIACVILQ KDATKQWFAE LNVDLDKVQE IVRAIVNLYE
LWKDWKEKDE IQMLLSKIPK PKPPPQR
