ID   CCNC_DROPS              Reviewed;         267 AA.
AC   Q29AI1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cyclin-C;
GN   Name=CycC; ORFNames=GA20234;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Cdk8 module of the Mediator complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM000070; EAL27369.1; -; Genomic_DNA.
DR   RefSeq; XP_001358231.1; XM_001358194.3.
DR   AlphaFoldDB; Q29AI1; -.
DR   SMR; Q29AI1; -.
DR   STRING; 7237.FBpp0282452; -.
DR   EnsemblMetazoa; FBtr0284014; FBpp0282452; FBgn0080229.
DR   GeneID; 4801070; -.
DR   KEGG; dpo:Dpse_GA20234; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_1_1_1; -.
DR   InParanoid; Q29AI1; -.
DR   OMA; SHHQQWL; -.
DR   PhylomeDB; Q29AI1; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0080229; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:EnsemblMetazoa.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0022416; P:chaeta development; IEA:EnsemblMetazoa.
DR   GO; GO:0036011; P:imaginal disc-derived leg segmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045498; P:sex comb development; IEA:EnsemblMetazoa.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR031658; Cyclin_C_2.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF16899; Cyclin_C_2; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..267
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000314262"
FT   DOMAIN          48..151
FT                   /note="Cyclin N-terminal"
SQ   SEQUENCE   267 AA;  31404 MW;  D625686EA7819709 CRC64;
     MAGNFWQSSH SQQWILDKQD LLRERQHDLL SLNEDEYQKV FIFFANVIQV LGEQLKLRQQ
     VIATATVYFK RFYARNSLKN IDPLLLAPTC ILLASKVEEF GVISNSRLIS ICQSAIKTKF
     SYAYTQEFPY RTNHILECEF YLLENLDCCL IVYQPYRPLL QLVQDMGQED QLLTLSWRIV
     NDSLRTDVCL LYPPYQIAIA CLQIACVILQ KDSTKQWFAE LNVDLDKVQE IVRAIVNLYE
     MWKDWKEKDE IQMLLSKIPK PKPPPQR